Forphenicine
- Product Name
- Forphenicine
- CAS No.
- 57784-96-0
- Chemical Name
- Forphenicine
- Synonyms
- Forphenicine;L-(+)-Forphenicin;α-Amino-4-formyl-3-hydroxybenzeneacetic acid;Benzeneacetic acid, α-amino-4-formyl-3-hydroxy-, (αS)-
- CBNumber
- CB11178811
- Molecular Formula
- C9H9NO4
- Formula Weight
- 195.17
- MOL File
- 57784-96-0.mol
Forphenicine Property
- Boiling point:
- 419.4±45.0 °C(Predicted)
- Density
- 1.485±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 1.62±0.10(Predicted)
- form
- A solid
Forphenicine Chemical Properties,Usage,Production
Biological Activity
Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 μg/ml for the chicken intestine enzyme).1 It inhibits the growth of HL-60 leukemia cells when used at a concentration of 10 μM.2 Forphenicine (50 and 500 μg/animal) increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE).3
References
1.Aoyagi, T., Yamamoto, T., Kojiri, K., et al.Forphenicine, and inhibitor of alkaline phosphatase produced by actinomycetesJ. Antibiot. (Tokyo)31(3)244-246(1978) 2.Miura, K., Sawa, T., Takeuchi, T., et al.Effects of enzyme inhibitors in inhibiting the growth and inducing the differentiation of human promyelocytic leukemia cells, HL-60J Antibiot (Tokyo)39(5)734-735(1986) 3.Aoyagi, T., Wada, T., Nagai, M., et al.Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitisExperientia40(12)1405-1407(1984)
Forphenicine Preparation Products And Raw materials
Raw materials
Preparation Products
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