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Naxagolide

Product Name
Naxagolide
CAS No.
88058-88-2
Chemical Name
Naxagolide
Synonyms
L-64739;CS-1515;(+)-PHNO;Naxagolida;Naxagolide;Naxagolidum;Naxagolide [inn];(+)-PHNO88058-88-2;Naxagolide free base;Naxagolide/Dopazinol
CBNumber
CB11179287
Molecular Formula
C15H21NO2
Formula Weight
247.336
MOL File
88058-88-2.mol
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Naxagolide Property

storage temp. 
Store at -20°C
solubility 
DMSO : 200 mg/mL (808.64 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0007626
Product name
DOPAZINOL
Purity
95.00%
Packaging
2.5MG
Price
$924
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181397
Product name
Naxagolide
Purity
>98%
Packaging
100mg
Price
$950.3
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181397
Product name
Naxagolide
Purity
>98%
Packaging
250mg
Price
$1876.8
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007626
Product name
DOPAZINOL
Purity
95.00%
Packaging
25MG
Price
$2001.04
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181397
Product name
Naxagolide
Purity
>98%
Packaging
1000mg
Price
$3728.1
Updated
2021/12/16
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Naxagolide Chemical Properties,Usage,Production

Uses

Antiparkinsonian;dopamine agonist.

Definition

ChEBI: Naxagolide is an organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued). It has a role as an antiparkinson drug, a dopamine agonist and an anticonvulsant. It is a tertiary amino compound, an organic heterotricyclic compound and a member of phenols. It is a conjugate base of a naxagolide(1+).

in vivo

In mice, Naxagolide ((+)-PHNO) produces hypothermia (13 μg/kg i.p.) and postural asymmetry in the unilaterally caudectomized animal (4 μg/kg i.p.)[1].
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1].

IC 50

D2 Receptor

Naxagolide Preparation Products And Raw materials

Raw materials

Preparation Products

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Naxagolide Suppliers

China 30 The Netherlands 1 United States 4 Global 35
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
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+86-21-52996696
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China
ProdList
4757
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55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
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info@angtibio.com
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China
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4985
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
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QQ:2853530913
Email
2853530910@QQ.com
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China
ProdList
8000
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
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China
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131957
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58
Amatek Scientific Co. Ltd.
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0512-56316828
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0512-56316826
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info@amateksci.com
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China
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Shanghai SPAR pharmaceutical technology co., LTD
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021-000000 13917643586;
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admin@jingshipharmatech.com
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China
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Taizhou Crene Biotechnology Co. Ltd.
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+86-0576-88813233 +86-13396860566
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sales@pharm-intermediates.com
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China
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Changzhou Chenhong Biotechnology Co., Ltd.
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+86-0519-85788828 +86-13775037613
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sales@chemrenpharm.com
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China
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career henan chemical co
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+86-0371-86658258 +8613203830695
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0086-371-86658258
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factory@coreychem.com
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China
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Absin Bioscience Inc.
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021-38015121 18438616290
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lanwu@univ-bio.com
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China
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Wuhan Topule
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Jinan Jiuli Biotechnology Co. , Ltd.
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Hangzhou FuRun Pharmaceutical Technology Co., Ltd
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NewCan Biotech Limited
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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Adooq Bioscience LLC
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400-025-6535
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sales@adooq.cn
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China
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Absin Bioscience Inc.
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chenjw@absin.cn
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Beijing Bai Ao Si Biotechnology Co., Ltd.
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Shanghai Benrui Biotechnology Co., Ltd.
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Wuhan Boot Biotechnology Co., Ltd.
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Shanghai Yuqi Biological Technology Co., Ltd.
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Beijing Fubo Biotechnology Co., Ltd.
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Xiamen Research Biotechnology Co., Ltd.
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Taizhou Crene Chempharm Co., Ltd.
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Shanghai Biochempartner Co., Ltd.
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Lanospharma Laboratories Co.,Ltd
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View Lastest Price from Naxagolide manufacturers

Career Henan Chemical Co
Product
Naxagolide 88058-88-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

88058-88-2, NaxagolideRelated Search:

3-PROPYLMORPHOLINE CIS-3,4-DIMETHYL-2-PHENYLMORPHOLINE 2-O-TOLYL-MORPHOLINE (S)-4-(3-AMINO-BUTYL)-PHENOL Phenylephrine hydrochloride (-)-Pseudoephedrine 7-AMINO-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-OL (1R,2R)-(-)-N-METHYLPSEUDOEPHEDRINE 3-Ethylmorpholine hydrochloride Phenmetrazine (R)-2-Methyl-morpholine (+)-3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol, Hydrochloride (R)-3-Methylmorpholine Naxagolide

  • (+)-4-Propyl-9-hydroxynaphoxazine
  • (4aR)-3,4,4aβ,5,6,10bα-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol
  • 4-Propyl-9-hydroxynaphoxazine
  • L-64739
  • 2H-Naphth(1,2-B)-1,4-oxazin-9-ol, 3,4,4A,5,6,10B-hexahydro-4-propyl-, (4ar-trans)-
  • Naxagolida
  • Naxagolida [inn-spanish]
  • Naxagolide [inn]
  • Naxagolidum
  • Naxagolidum [inn-latin]
  • (4aR,10bR)-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol
  • (+)-PHNO88058-88-2
  • (+)-PHNO
  • Naxagolide
  • 4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine
  • CS-1515
  • NAXAGOLIDE [INN]; PHNO; NAXAGOLIDUM [INN-LATIN]; NAXAGOLIDA [INN-SPANISH]; 88058-88-2
  • 2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR,10bR)-
  • Naxagolide free base
  • Naxagolide/Dopazinol
  • 88058-88-2