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(R)-3-Methylmorpholine

Product Name
(R)-3-Methylmorpholine
CAS No.
74572-04-6
Chemical Name
(R)-3-Methylmorpholine
Synonyms
(R)-3-MethyL;R-methylmorpholine-D7;(R)-3-Methylmorpholine;elagolix intermediate 8;Morpholine, 3-methyl-, (R)-;Morpholine, 3-Methyl-, (3R)-;(R)-3-Methylmorpholine(WX900060);(R)-3-MethylmorpholineortheHClsalt;high quality (R)-3-Methylmorpholine
CBNumber
CB31561899
Molecular Formula
C5H11NO
Formula Weight
101.15
MOL File
74572-04-6.mol
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(R)-3-Methylmorpholine Property

Boiling point:
137.1±15.0 °C(Predicted)
Density 
0.891±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
9.03±0.40(Predicted)
form 
liquid
color 
Colourless
InChI
InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
InChIKey
SFWWGMKXCYLZEG-RXMQYKEDSA-N
SMILES
N1CCOC[C@H]1C
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M325205
Product name
(R)-3-Methylmorpholine
Packaging
25g
Price
$970
Updated
2021/12/16
Apolloscientific
Product number
OR308175
Product name
(3R)-3-Methylmorpholine
Packaging
1g
Price
$29
Updated
2021/12/16
Activate Scientific
Product number
AS3425
Product name
(R)-3-Methylmorpholine
Purity
97+% ee
Packaging
1g
Price
$47
Updated
2021/12/16
Apolloscientific
Product number
OR308175
Product name
(3R)-3-Methylmorpholine
Packaging
5g
Price
$87
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-9Y
Product name
(R)-3-Methylmorpholine
Packaging
5G
Price
$96
Updated
2021/12/16
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(R)-3-Methylmorpholine Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

(R)-3-Methylmorpholine is useful for the discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one, an inhibitor of Vps34 for the treatment of solid tumors.

Synthesis

119844-67-6

74572-04-6

GENERAL STEPS: A tetrahydrofuran (THF, 100 mL) solution of lithium aluminum hydride (LAH, 2 eq.) was cooled to 0 °C in an ice bath under nitrogen protection. A solution of (R)-5-methylmorpholin-3-one (1 eq.) in THF (20 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was cooled again to 0 °C and quenched by careful addition of water (2 mL), 2N sodium hydroxide solution (2 mL) and water (8 mL) in that order. After quenching, the resulting slurry was stirred at room temperature for 1 hour and then filtered through diatomaceous earth. The filter cake was washed with ethyl acetate and discarded. The filtrate was dried with anhydrous sodium sulfate, separated and concentrated to give (R)-3-methylmorpholine as a colorless oil.

References

[1] Synthesis (Germany), 2014, vol. 46,
[2] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 149

(R)-3-Methylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-Methylmorpholine Suppliers

China 183 Germany 2 India 5 United Kingdom 1 United States 12 Global 203
Shanghai Finechem Biotechnology Co., Ltd.
Tel
15821337685
Email
hwh-chem@163.com
Country
China
ProdList
98
Advantage
58
Doly Chemical CO.,LTD.
Tel
021-34716221 15800796336
Fax
+86-21-31329566
Email
sales@dolypharm.com
Country
China
ProdList
289
Advantage
55
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2809
Advantage
65
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
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View Lastest Price from (R)-3-Methylmorpholine manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-methylmorpholine 74572-04-6
Price
US $6.70/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-methylmorpholine 74572-04-6
Price
US $6.70/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2021-11-26
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-Methylmorpholine 74572-04-6
Price
US $6.70/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-11-26

74572-04-6, (R)-3-MethylmorpholineRelated Search:

Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Naxagolide Methscopolamine bromide Scopolamine hydrobromide (5R)-3,4,5,6-Tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one HYOSCINE HYDROCHLORIDE Scopolamine butylbromide Voxergolide SCOPOLAMINE METHYL NITRATE SCOPOLAMINE N-OXIDE HYDROBROMIDE Anisodine hydrobromide Scopine hydrochloride tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate APOHYOSCINE (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Anisodine (-)-SCOPOLAMINE PERCHLORATE SCOPOLAMINE METHYL CHLORIDE, [N-METHYL-3H]

  • (R)-3-Methylmorpholine
  • (R)-3-MethylmorpholineortheHClsalt
  • Morpholine, 3-Methyl-, (3R)-
  • Morpholine, 3-methyl-, (R)-
  • (R)-3-Methylmorpholine(WX900060)
  • elagolix intermediate 8
  • (R)-3-MethyL
  • R-methylmorpholine-D7
  • high quality (R)-3-Methylmorpholine
  • 74572-04-6