(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

Product Name: (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
CAS No.: 300576-59-4
Chemical Name: (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
Synonyms: (+/-)-PD 128;(+)PD 128907;(+)-PD 128970 HCl;(+)-PD 128907 HCl;(+)-PD 128907 HCl, >=98%;(+)-PD 128907 HYDROCHLORIDE;(+/-)-PD 128,907 HYDROCHLORIDE;(+)-PD 128907 hydrochloride, 10 mM in DMSO;(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol;(4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride
CBNumber: CB22129471
Molecular Formula: C14H19NO3HCl
Formula Weight: 285.77
MOL File: 300576-59-4.mol

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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: ethanol: >10mg/mL
form: solid
color: off-white
Water Solubility: Soluble to 10 mM in water
InChIKey: DCFXOTRONMKUJB-QMDUSEKHSA-N

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Safety

Safety Statements: 24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P183
Product name: (+)-PD 128,907 hydrochloride
Purity: >97%, solid
Packaging: 5mg
Price: $601
Updated: 2023/01/07

Sigma-Aldrich

Product number: P183
Product name: (+)-PD 128,907 hydrochloride
Purity: >97%, solid
Packaging: 25mg
Price: $2100
Updated: 2022/05/15

Cayman Chemical

Product number: 21235
Product name: (+)-PD 128907 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21235
Product name: (+)-PD 128907 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21235
Product name: (+)-PD 128907 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Chemical Properties,Usage,Production

Uses

(+)-PD 128907 Hydrochloride is a potent D3 receptor agonist.

Biological Activity

Potent D 3 dopamine receptor agonist (K i = 2.3 nM). Displays 18-200-fold selectivity over other dopamine receptor subtypes.

in vivo

(+)-PD 128907 significantly decreases dialysate DA levels in D₃ knock out mice. The IC₂₅ values are 61 nM and 1327 nM, respectively, for wild type and D₃knock out mice. The ratio of the IC₂₅ values shows that (+)-PD 128907 is 22 times more potent in decreasing dialysate DA levels in wild type as compared to mice lacking the D₃ receptor. The D3 agonist evokes a dose related decrease in dialysate DA in wild type mice. Post-hoc analysis shows that all doses tested (0.03, 0.1 and 0.3 mg/kg) significantly inhibit dialysate DA. The IC₂₅ values are 0.05 and 0.44 mg/kg for wild type and knock out mice, respectively, indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D₃ knock out mice. Doses of 1 mg/kg or higher of (+)-PD 128907 markedly inhibits dialysate DA in both wild type and D₃ knock out mice^[3].

IC 50

D₃ Receptor; D₂ Receptor

storage

Store at +4°C

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Suppliers

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300576-59-4, (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochlorideRelated Search:

(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol (-)-Pseudoephedrine Phenylephrine hydrochloride Phenylephrine DL-PHENYLEPHRINE HYDROCHLORIDE DL-Methylephedrine hydrochloride (R)-2-Methyl-morpholine Phenmetrazine (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL (R*,R*)-alpha-(1-aminoethyl)benzyl alcohol (±)-alpha-[(ethylamino)methyl]-m-hydroxybenzyl alcohol (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride 3(R)-HYDROXYMETHYLMORPHOLINE N-ETHYL-2-METHOXY-BENZENEETHANAMINE 2-(2-aminopropyl)phenol (+)-PD 128907 HYDROCHLORIDE CHEMBRDG-BB 5740188 2-[(1-methyl-2-phenoxyethyl)amino]ethanol

(+/-)-PD 128,907 HYDROCHLORIDE

(+)-PD 128907 HYDROCHLORIDE

(+)-(4ar,10br)-3,4,4a,10b-tetrahydro-4-propyl-2h,5h-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

(S)-(+)-(4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride

(4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-olhydrochloride

(4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride

(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol

(+/-)-PD 128

(+)-PD 128907 HCl, >=98%

(+)-PD 128970 HCl

(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, hydrochloride

(4aR,10aR)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-azaphenanthren-6-ol hydrochloride

(4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride

(+)-PD 128907,Dopamine Receptor,inhibit,(+) PD 128907 hydrochloride,Inhibitor,(+)PD 128907 hydrochloride

(+)PD 128907

(+)-PD 128907 HCl

(+)-PD 128907 hydrochloride, 10 mM in DMSO

300576-59-4

Dopamine receptor