3(R)-HYDROXYMETHYLMORPHOLINE
- Product Name
- 3(R)-HYDROXYMETHYLMORPHOLINE
- CAS No.
- 211053-49-5
- Chemical Name
- 3(R)-HYDROXYMETHYLMORPHOLINE
- Synonyms
- (R)-3-Morpholinemethanol;(3R)-3-Morpholinemethanol;(R)-morpholin-3-ylmethanol;(3R)-morpholine-3-methanol;3-MorpholineMethanol, (3R)-;3(R)-HYDROXYMETHYLMORPHOLINE;((3R)-Morpholin-3-yl)methanol;(R)-3-Hydroxymethylmorpholine;(3R)-3-Morpholinemethanol,99%e.e.;3(R)-HYDROXYMETHYLMORPHOLINE HCL,
- CBNumber
- CB8367459
- Molecular Formula
- C5H11NO2
- Formula Weight
- 117.15
- MOL File
- 211053-49-5.mol
3(R)-HYDROXYMETHYLMORPHOLINE Property
- Melting point:
- 78-81°C
- Boiling point:
- 218℃
- Density
- 1.045
- Flash point:
- 86℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform
- form
- Solid
- pka
- 14.85±0.10(Predicted)
- color
- White to Off-White
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H947975
- Product name
- (3R)-Hydroxymethylmorpholine
- Packaging
- 500mg
- Price
- $855
- Updated
- 2021/12/16
- Product number
- 075775
- Product name
- (R)-3-Hydroxymethylmorpholine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $239
- Updated
- 2021/12/16
- Product number
- 075775
- Product name
- (R)-3-Hydroxymethylmorpholine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CCH0040056
- Product name
- (3R)-HYDROXYMETHYLMORPHOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.23
- Updated
- 2021/12/16
- Product number
- CHM0022522
- Product name
- 3(R)-HYDROXYMETHYL MORPHOLINE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $693
- Updated
- 2021/12/16
3(R)-HYDROXYMETHYLMORPHOLINE Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
A chiral morpholine drivative.
Synthesis
101376-26-5
211053-49-5
General procedure for the synthesis of (R)-3-hydroxymethylmorpholine from (R)-(4-benzyl-3-morpholinyl)-methanol: (a) Preparation of (3R)-morpholin-3-ylmethanol: [(3R)-4-benzylmorpholin-3-yl]methanol (cf. J. Med. Chem.; 29; 1986; 1288-1290; 1.1 g, 5.4 mmol) was dissolved in ethanol (25 mL), palladium hydroxide (20% loaded on activated carbon, 0.7 g) and acetic acid (0.5 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.2 bar). After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation under reduced pressure. The residue except 200 mg was dissolved in ether (1 mL) and tetrahydrofuran (10 mL). The solution was purified by passing it through a strong cation exchange column (Isolute SCX-2, 10 g). The column was first washed with tetrahydrofuran, followed by elution of the target product with ammonia-saturated methanol. The solvent was removed by evaporation under reduced pressure to give 0.3625 g (57% yield) of (3R)-morpholin-3-ylmethanol as an oil.1H NMR (500 MHz, CD3OD): δ 2.9 (m, 3H), 3.3 (t, 1H), 3.5 (m, 3H), 3.7-3.9 (m, 2H).
References
[1] Patent: WO2006/137790, 2006, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244
3(R)-HYDROXYMETHYLMORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3(R)-HYDROXYMETHYLMORPHOLINE manufacturers
- Product
- 3(R)-HYDROXYMETHYLMORPHOLINE 211053-49-5
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-19