AC480 (BMS-599626)

Product Name: AC480 (BMS-599626)
CAS No.: 714971-09-2
Chemical Name: AC480 (BMS-599626)
Synonyms: AC-480;CS-341;CS-1550;NSC133463;BMS-599616;NSC 133463;NSC-133463;BMS 599626 ;AC480 (BMS-599626);BMS599626 Free base
CBNumber: CB12464670
Molecular Formula: C27H27FN8O3
Formula Weight: 530.55
MOL File: 714971-09-2.mol

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AC480 (BMS-599626) Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥28.35 mg/mL in DMSO
form: powder to crystal
pka: 7.27±0.46(Predicted)
color: White to Light yellow to Light orange
CAS DataBase Reference: 714971-09-2

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5520
Product name: BMS-599626
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $200
Updated: 2025/07/31

TCI Chemical

Product number: B5520
Product name: BMS-599626
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $694
Updated: 2025/07/31

Cayman Chemical

Product number: 29657
Product name: AC480
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 29657
Product name: AC480
Packaging: 25mg
Price: $510
Updated: 2024/03/01

Cayman Chemical

Product number: 29657
Product name: AC480
Packaging: 1mg
Price: $36
Updated: 2024/03/01

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AC480 (BMS-599626) Chemical Properties,Usage,Production

Uses

BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.

Uses

It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhibiting tumors in which receptor coexpression and heterodimerization play a major role in driving tumor growth.

Biological Activity

ac480 (bms-599626) is a potent, selective inhibitor of human epidermal growth factor receptor (her) that inhibits her1 and her2 with ic values of 20 nm and 30 nm, respectively. ac480 has been proved to inhibit her1 in an atp-competitive manner. on the contrary, ac480 has shown to be an atp noncompetitive inhibitor of her2 [1]ac480 inhibited the proliferation of sal2 cells derived from a transgenic mouse tumor, breast tumor and gastric carcinoma cell lines, geo colon tumor cells, non–small-cell lung tumor cells line via her1 and/or her2 signalings [1].ac480 by oral administration has been demonstrated to suppress the growth of sal2 tumor, geo xenograft tumor, kpl-4 and bt474 breast tumors, n87 gastric tumor, a549 and l2987 non–small-cell lung tumors in nude mice [1].

in vivo

BMS-599626 (60-240 mg/kg; p.o.; daily for 14 days) results in a dose-dependent inhibition of Sal2 tumor growth^[1].
BMS599626 treatment results in the inhibition of GEO xenograft tumor growth when given once daily for 14 days. In addition to efficacy in the Sal2, GEO, and KPL4 models, BMS-599626 has similar antitumor activity in other HER2 amplified xenograft models including the BT474 breast and N87 gastric tumors, as well as other HER1-overexpressing non-small-cell lung tumors (A549 and L2987)^[1].
BMS599626 given before and during irradiation improved the radioresponse of HN5 tumors in vivo^[2].

Animal Model:	Athymic female nude mice (nu/nu mice, Sal2 tumor model)^[1]
Dosage:	60, 120, 240 mg/kg
Administration:	Oral; daily for 14 days
Result:	Resulted in a dose-dependent inhibition of Sal2 tumor growth.

target

HER1

References

[1] wong tw1, lee fy, yu c, luo fr, oppenheimer s, zhang h, smykla ra, mastalerz h, fink be, hunt jt,gavai av, vite gd. preclinical antitumor activity of bms-599626, a pan-her kinase inhibitor that inhibits her1/her2 homodimer and heterodimer signaling. clin cancer res. 2006 oct 15;12(20 pt 1):6186-93.

AC480 (BMS-599626) Preparation Products And Raw materials

Raw materials

Preparation Products

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AC480 (BMS-599626) Suppliers

Americas 1 Canada 1 China 106 Europe 1 India 2 Japan 1 United Kingdom 1 United States 16 Global 129

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714971-09-2, AC480 (BMS-599626)Related Search:

Tariquidar (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Torin 1 Telaprevir Avagacestat (BMS-708163) RO4929097 Brivanib alaninate XL413 (BMS-863233) Tamoxifen citrate Toremifene citrate Entinostat CUDC-101 Olaparib AC480 (BMS-599626) 3(R)-HYDROXYMETHYLMORPHOLINE PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE 5-Amino-1-(3-fluorobenzyl)indazole

Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester (9CI)

AC-480

N-[4-[[1-[(3-Fluorophenyl)Methyl]-1H-indazol-5-yl]aMino]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbaMic Acid (3S)-3-MorpholinylMethyl Ester

(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,

AC480 (BMS-599626)

(S)-morpholin-3-ylmethyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-ylcarbamate

(3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate

[(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrrolo

CS-341

CS-1550

BMS599626;AC-480; BMS 599626 (AC480)

BMS-599616

BMS599626 Free base

[(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrr

(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f]

(S)-MORPHOLIN-3-YLMETHYL 4-(1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YLAMINO)-5-METHYLPYRROLO[2,1-F][1,2,4]-TRIAZIN-6-YLCARBAMATE

CARBAMIC ACID, [4-[[1-[(3-FLUOROPHENYL)METHYL]-1H-INDAZOL-5-YL]AMINO]-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]-, (3S)-3-MORPHOLINYLMETHYL ESTER

BMS 599626

Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester

AC480 (BMS-599626) USP/EP/BP

NSC 133463

NSC133463

NSC-133463

BMS-599626 BMS599626 AC480

AC480 (BMS-599626) ，S1056

714971-09-2

8173837-23-1

C26H25FN8O3

C27H27FN8O3

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals