CUDC-101

Product Name: CUDC-101
CAS No.: 1012054-59-9
Chemical Name: CUDC-101
Synonyms: CURIS;CS-330;CUDC101;CUDC-101;CUDC-101, >=98%;CUDC101;CUDC 101;CUDC101; CUDC 101; CUDC-101.;7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide;7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide;7-[[4-[(3-Ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanaMide
CBNumber: CB12500941
Molecular Formula: C24H26N4O4
Formula Weight: 434.49
MOL File: 1012054-59-9.mol

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CUDC-101 Property

Melting point:: 174-177℃
Density: 1.28
storage temp.: -20°C
solubility: DMSO: soluble
form: solid
pka: 9.47±0.20(Predicted)
color: White or off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: PLIVFNIUGLLCEK-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: EPS003
Product name: CUDC 101
Purity: A potent inhibitor of HDACs and receptor tyrosine kinases
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: EPS003
Product name: CUDC 101
Purity: A potent inhibitor of HDACs and receptor tyrosine kinases
Packaging: 25mg
Price: $692
Updated: 2023/01/07

Cayman Chemical

Product number: 16426
Product name: CUDC 101
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 16426
Product name: CUDC 101
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 16426
Product name: CUDC 101
Purity: ≥98%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

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CUDC-101 Chemical Properties,Usage,Production

Description

CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,? IC50?= 4.4, 2.4 and 15.7 nM respectively.1?It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.1,2

Uses

Inhibitor of HDAC, EGFR, and HER2 with an IC50 of 4.4, 2.4, and 15.7 nM, respectively.

Uses

CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer.

General Description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

target

EGFR

References

1) Lai?et al. (2010),?CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potential anticancer activity; Cancer Res.,?70?3647 2) Cai?et al.?(2010), Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer; J. Med. Chem.,?53?2000

CUDC-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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CUDC-101 Suppliers

Canada 1 China 104 India 2 United Kingdom 2 United States 18 Global 127

J & K SCIENTIFIC LTD.

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China Langchem Inc.

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Beijing HuaMeiHuLiBiological Chemical

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1012054-59-9, CUDC-101Related Search:

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CUDC101

CUDC-101

7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide

CUDC101; CUDC 101; CUDC-101.

CS-330

CUDC101;CUDC 101

HeptanaMide, 7-[[4-[(3-ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxy-

7-[[4-[(3-Ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanaMide

7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide CUDC-101

7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide

CUDC-101, >=98%

CURIS

1012054-59-9

Inhibitor

Antineoplastic

Inhibitors