CUDC-101
- Product Name
- CUDC-101
- CAS No.
- 1012054-59-9
- Chemical Name
- CUDC-101
- Synonyms
- CURIS;CS-330;CUDC101;CUDC-101;CUDC-101, >=98%;CUDC101;CUDC 101;CUDC101; CUDC 101; CUDC-101.;7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide;7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide;7-[[4-[(3-Ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanaMide
- CBNumber
- CB12500941
- Molecular Formula
- C24H26N4O4
- Formula Weight
- 434.49
- MOL File
- 1012054-59-9.mol
CUDC-101 Property
- Melting point:
- 174-177℃
- Density
- 1.28
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 9.47±0.20(Predicted)
- color
- White or off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- PLIVFNIUGLLCEK-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- EPS003
- Product name
- CUDC 101
- Purity
- A potent inhibitor of HDACs and receptor tyrosine kinases
- Packaging
- 5mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- EPS003
- Product name
- CUDC 101
- Purity
- A potent inhibitor of HDACs and receptor tyrosine kinases
- Packaging
- 25mg
- Price
- $692
- Updated
- 2023/01/07
- Product number
- 16426
- Product name
- CUDC 101
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 16426
- Product name
- CUDC 101
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 16426
- Product name
- CUDC 101
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
CUDC-101 Chemical Properties,Usage,Production
Description
CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,? IC50?= 4.4, 2.4 and 15.7 nM respectively.1?It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.1,2
Uses
Inhibitor of HDAC, EGFR, and HER2 with an IC50 of 4.4, 2.4, and 15.7 nM, respectively.
Uses
CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer.
General Description
A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.
Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.
target
EGFR
References
1) Lai?et al. (2010),?CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potential anticancer activity; Cancer Res.,?70?3647 2) Cai?et al.?(2010), Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer; J. Med. Chem.,?53?2000
CUDC-101 Preparation Products And Raw materials
Raw materials
Preparation Products
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