ChemicalBook > CAS DataBase List > CUDC-101

CUDC-101

Product Name
CUDC-101
CAS No.
1012054-59-9
Chemical Name
CUDC-101
Synonyms
CURIS;CS-330;CUDC101;CUDC-101;CUDC-101, >=98%;CUDC101;CUDC 101;CUDC-101, 10 mM in DMSO;CUDC101; CUDC 101; CUDC-101.;7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide;7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide
CBNumber
CB12500941
Molecular Formula
C24H26N4O4
Formula Weight
434.49
MOL File
1012054-59-9.mol
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CUDC-101 Property

Melting point:
174-177℃
Density 
1.28
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
pka
9.47±0.20(Predicted)
color 
White or off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey
PLIVFNIUGLLCEK-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
EPS003
Product name
CUDC 101
Purity
A potent inhibitor of HDACs and receptor tyrosine kinases
Packaging
5mg
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
EPS003
Product name
CUDC 101
Purity
A potent inhibitor of HDACs and receptor tyrosine kinases
Packaging
25mg
Price
$692
Updated
2023/01/07
Cayman Chemical
Product number
16426
Product name
CUDC 101
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
16426
Product name
CUDC 101
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
16426
Product name
CUDC 101
Purity
≥98%
Packaging
25mg
Price
$324
Updated
2024/03/01
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CUDC-101 Chemical Properties,Usage,Production

Description

CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,? IC50?= 4.4, 2.4 and 15.7 nM respectively.1?It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.1,2

Uses

Inhibitor of HDAC, EGFR, and HER2 with an IC50 of 4.4, 2.4, and 15.7 nM, respectively.

Uses

CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer.

General Description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

target

EGFR

References

1) Lai?et al. (2010),?CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potential anticancer activity; Cancer Res.,?70?3647 2) Cai?et al.?(2010), Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer; J. Med. Chem.,?53?2000

CUDC-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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1012054-59-9, CUDC-101Related Search:

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  • CUDC101
  • CUDC-101
  • 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide
  • CUDC101; CUDC 101; CUDC-101.
  • CS-330
  • CUDC101;CUDC 101
  • HeptanaMide, 7-[[4-[(3-ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxy-
  • 7-[[4-[(3-Ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanaMide
  • 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide CUDC-101
  • 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide
  • CUDC-101, >=98%
  • CURIS
  • CUDC-101, 10 mM in DMSO
  • 1012054-59-9
  • Inhibitor
  • Antineoplastic
  • Inhibitors