3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- Product Name
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- CAS No.
- 677297-51-7
- Chemical Name
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- Synonyms
- CS-427;100-115;TG100-115, >=98%;TG100115; TG100 115;TG100-115;TG100115;TG100 115;3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno;3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol;3,3'-(2,4-Diaminopteridine-6,7-diyl)diphenol;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine;3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- CBNumber
- CB82484695
- Molecular Formula
- C18H14N6O2
- Formula Weight
- 346.34
- MOL File
- 677297-51-7.mol
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Property
- Boiling point:
- 699.6±65.0 °C(Predicted)
- Density
- 1.516±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO
- form
- Yellow powder solid.
- pka
- 8.54±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- T337795
- Product name
- TG100-115
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- SYN1105
- Product name
- TG100115
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- INB0000880
- Product name
- TG-100115
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $9799.02
- Updated
- 2021/12/16
- Product number
- CS-0186
- Product name
- TG100-115
- Purity
- 99.31%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- FB43326
- Product name
- 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Chemical Properties,Usage,Production
Uses
TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function.
Definition
ChEBI: 3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol is a member of pteridines.
Biological Activity
tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2].
target
PI3K-γ
References
[1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.
[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65.
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol manufacturers
- Product
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno 677297-51-7
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-18
- Product
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol 677297-51-7
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23