3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

ChemicalBook > CAS DataBase List > 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

Product Name: 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
CAS No.: 677297-51-7
Chemical Name: 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
Synonyms: CS-427;100-115;T 100-115;TG100-115, >=98%;TG100115; TG100 115;TG100-115;TG100115;TG100 115;3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno;3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol;3,3'-(2,4-Diaminopteridine-6,7-diyl)diphenol;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
CBNumber: CB82484695
Molecular Formula: C18H14N6O2
Formula Weight: 346.34
MOL File: 677297-51-7.mol

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3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Property

Boiling point:: 699.6±65.0 °C(Predicted)
Density: 1.516±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO
form: Yellow powder solid.
pka: 8.54±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T337795
Product name: TG100-115
Packaging: 10mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: SYN1105
Product name: TG100115
Packaging: 1mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000880
Product name: TG-100115
Purity: 95.00%
Packaging: 1G
Price: $9799.02
Updated: 2021/12/16

ChemScene

Product number: CS-0186
Product name: TG100-115
Purity: 99.31%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43326
Product name: 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine
Packaging: 25mg
Price: $100
Updated: 2021/12/16

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3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Chemical Properties,Usage,Production

Uses

TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function.

Definition

ChEBI: 3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol is a member of pteridines.

Biological Activity

tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2].

target

PI3K-γ

References

[1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.
[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65.

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Preparation Products And Raw materials

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View Lastest Price from 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: 3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno 677297-51-7
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-18

Career Henan Chemical Co

Product: 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol 677297-51-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

677297-51-7, 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenolRelated Search:

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3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol

TG100-115;TG100115;TG100 115

6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol TG100-115

TG100-115, >=98%

TG100115; TG100 115

CS-427

100-115

Phenol, 3,3'-(2,4-diamino-6,7-pteridinediyl)bis-

3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno

PI3K,TG100 115,Phosphoinositide 3-kinase,inhibit,TG-100-115,TG100-115,Inhibitor,TG100115

3,3'-(2,4-Diaminopteridine-6,7-diyl)diphenol

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

T 100-115

677297-51-7

Inhibitors

Akt

mTOR

PI3K

APIs