5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
- Product Name
- 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
- CAS No.
- 958852-01-2
- Chemical Name
- 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
- Synonyms
- CS-536;CS-1726;GSK-615;CS-1156;SK1059615;GSK 1059615;GSK 1059615;GSK-1059615;PI3K inhibitor GS1059615;GSK 1059615 SodiuM Salt Hydrate;GSK1059615;GSK 1059615; GSK-1059615
- CBNumber
- CB62518985
- Molecular Formula
- C18H11N3O2S
- Formula Weight
- 333.36
- MOL File
- 958852-01-2.mol
5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Property
- Melting point:
- >290°C (dec.)
- storage temp.
- Store at +4°C
- solubility
- H2O: ≥8mg/mL
- form
- powder
- color
- yellow
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0083
- Product name
- GSK 1059615 sodium salt hydrate
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- SML0083
- Product name
- GSK 1059615 sodium salt hydrate
- Packaging
- 50mg
- Price
- $489
- Updated
- 2024/03/01
- Product number
- 11569
- Product name
- GSK1059615
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 11569
- Product name
- GSK1059615
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 11569
- Product name
- GSK1059615
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $252
- Updated
- 2024/03/01
5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Chemical Properties,Usage,Production
Uses
GSK 1059615 is a potent inhibitor of PI 3-kinase and FRAP (mTOR).
Uses
GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα). GSK 1059615 inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Definition
ChEBI: GSK1059615 is a thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a member of quinolines, a member of pyridines and a thiazolidinone.
Biological Activity
gsk1059615 is inhibitor of pan-pi3k with ic50 values of 0.4nm, 0.6nm, 5nm, 2nm and 12nm for pi3kα, p13kβ, p13kγ, p13kδ and mtor, respectively [1].gsk1059615 is a potent and reversible inhibitor of p13k. it also has inhibition efficacy to the oncogenic mutants of pi3kα. the thiazolidinedione ring of gsk1059615 forms an interaction with the catalytic lysine (lys833) within the atp-binding pocket. in cellular assay, gsk1059615 is reported to induce g1 arrest and apoptosis in a variety of cell lines. among these, the breast tumor cells display more sensitive. moreover, gsk1059615 significantly suppresses tumor growth and increases plasma insulin levels in xenograft mice [1, 2].
References
[1] carnero a. novel inhibitors of the pi3k family. 2009.
[2] knight s d, adams n d, burgess j l, et al. discovery of gsk2126458, a highly potent inhibitor of pi3k and the mammalian target of rapamycin. acs medicinal chemistry letters, 2010, 1(1): 39-43.
5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione manufacturers
- Product
- 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione 958852-01-2
- Price
- US $1000.00-950.00/KG
- Min. Order
- 1MG
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-04