MET small molecule inhibitor Originator
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Capmatinib

MET small molecule inhibitor Originator
Product Name
Capmatinib
CAS No.
1029712-80-8
Chemical Name
Capmatinib
Synonyms
INC280;INCB28060;INC28060;2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide;NC280;CS-192;INCB028060;NVP-INC280;CapMatinib;Karma for,
CBNumber
CB92574678
Molecular Formula
C23H17FN6O
Formula Weight
412.42
MOL File
1029712-80-8.mol
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Capmatinib Property

Melting point:
>250°C (dec.)
Density 
1.40
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
13.82±0.46(Predicted)
form 
Solid
color 
Pale Yellow to Light Yellow
InChI
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey
LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES
C(NC)(=O)C1=CC=C(C2=NN3C(CC4=CC=C5C(=C4)C=CC=N5)=CN=C3N=C2)C=C1F
LogP
1.6-2.2 at 35℃ and pH7-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20056
Product name
INCB 28060
Purity
≥98%
Packaging
5mg
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
20056
Product name
INCB 28060
Purity
≥98%
Packaging
10mg
Price
$157
Updated
2024/03/01
Cayman Chemical
Product number
20056
Product name
INCB 28060
Purity
≥98%
Packaging
50mg
Price
$647
Updated
2024/03/01
Biosynth Carbosynth
Product number
FF40658
Product name
Capmatinib
Packaging
500mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-1541
Product name
Capmatinib
Purity
99.92%
Packaging
200mg
Price
$190
Updated
2021/12/16
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Capmatinib Chemical Properties,Usage,Production

MET small molecule inhibitor

Capmatinib(Synonyms: INC280; INCB28060) is a competitive inhibitor with very potent and selective activity against MET compared to other kinases. It has been shown in vitro that cell lines made resistant to erlotinib, an EGFR inhibitor, could be resensitized after capmatinib treatment. Results from a phase Ib/II study of patients with EGFR-mutated, MET-dysregulated NSCLC have shown promising responses to a combination of capmatinib and gefitinib (EGFR TKI) following disease progression from an only EGFR TKI treatment regimen. Recommended phase II dose was determined to be capmatinib 400 mg twice/day and gefitinib 250 mg once/day. Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.

Originator

Novartis

Description

Capmatinib is a competitive inhibitor with very potent and selective activity against MET compared to other kinases.

Description

INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells. INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice. It also improves efficacy of gemcitabine in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.

Uses

2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide is used in the preparation of a combination formulation with allosteric SHP2 inhibitor TNO155. Used in treatment of non-small cell lung cancer with specific mutations (those that lead to mesenchymal-epithelial transition or MET exon 14 skipping).

Side effects

Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.

in vitro

It has been shown in vitro that cell lines made resistant to erlotinib, an EGFR inhibitor, could be resensitized after capmatinib treatment. Results from a phase Ib/II study of patients with EGFR-mutated, MET-dysregulated NSCLC have shown promising responses to a combination of capmatinib and gefitinib (EGFR TKI) following disease progression from an only EGFR TKI treatment regimen. Recommended phase II dose was determined to be capmatinib 400 mg twice/day and gefitinib 250 mg once/day.

target

c-MET

References

1. liu x, wang q, yang g, et al. a novel kinase inhibitor, incb28060, blocks c-met-dependent signaling, neoplastic activities, and cross-talk with egfr and her-3. clinical cancer research : an official journal of the american association for cancer research. 2011;17(22):7127-7138.

Capmatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Capmatinib Suppliers

Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025,68780026 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
161
Advantage
62
Shanghai Hope Chem Co., Ltd.,
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
431
Advantage
55
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9979
Advantage
58
Changzhou Borl Biotechnology Co.,LTD
Tel
13606124132;13656121842
Email
luyan0021@163.com
Country
China
ProdList
219
Advantage
58
Jinan XinKe Pharmaceutical Technology Co., Ltd.
Tel
0531-88259693 17854196142
Fax
0531-88259693
Email
2820602043@qq.com
Country
China
ProdList
73
Advantage
58
Tianjin Zhongcheng Mingyuan Technology Co., Ltd.
Tel
13302022156
Fax
-
Email
3506745780@qq.com
Country
China
ProdList
171
Advantage
58
Suzhou Haijing Pharmaceutical Technology Co., Ltd
Tel
0512-62992936 17786580220
Email
2503890038@qq.com
Country
China
ProdList
90
Advantage
58
Suzhou Albertchem Co.,Ltd.
Tel
0512-88968486 18012631750
Email
sales@albertchemical.com
Country
China
ProdList
268
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
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View Lastest Price from Capmatinib manufacturers

shandong perfect biotechnology co.ltd
Product
Capmatinib 1029712-80-8
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1KG
Release date
2023-08-02
Wuhan Biocar Pharmacy Co., Ltd.
Product
Capmatinib 1029712-80-8
Price
US $9.90-9.90/g
Min. Order
5g
Purity
99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
Supply Ability
10kg
Release date
2022-10-08
Nanjing Fred Technology Co., Ltd
Product
Capmatinib 1029712-80-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%,single impurity<0.1
Supply Ability
1 ton
Release date
2023-12-21

1029712-80-8, CapmatinibRelated Search:


  • INCB028060
  • CapMatinib (INCB28060)
  • CapMatinib
  • NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • NVP-INC280
  • 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060)
  • INCB28060, INC280
  • INC28060
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- INCB28060
  • INC28060(BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-)
  • INC 280 (INCB28060)
  • INCB28060(Capmatinib)
  • CS-192
  • INCB 28060; INCB-28060; INC280
  • INC280 Capmatinib
  • CAPMATINIB (INC280)
  • BenzaMide INCB28060
  • BenzaMide HCl
  • CAPMATINIB (INCB28060);INCB-28060; INC-280
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • INCB28060
  • 2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide
  • INC280
  • INCB28060,BenzaMide
  • NC280
  • 2-fluoro-n-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide capmatinib
  • Capmatinib base
  • 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
  • Capmatinib USP/EP/BP
  • Karma for,
  • Valproic Acid Impurity 69
  • 1029712-80-8
  • C23H17FN6O
  • Inhibitors
  • API