GSK1838705A
- Product Name
- GSK1838705A
- CAS No.
- 1116235-97-2
- Chemical Name
- GSK1838705A
- Synonyms
- GSK1838705;CS-236;GSK1838705A;GSK1838705A USP/EP/BP;GSK1838705A >=98% (HPLC);2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide;2-[[2-[[1-[2-(Dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methy;2-[[2-[[1-[2-(Dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide;Benzamide, 2-[[2-[[1-[2-(dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methyl-;2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide
- CBNumber
- CB72605356
- Molecular Formula
- C27H29FN8O3
- Formula Weight
- 532.57
- MOL File
- 1116235-97-2.mol
GSK1838705A Property
- Density
- 1.399
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 13.27±0.50(Predicted)
- color
- white to light brown
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0995
- Product name
- GSK1838705A
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- SML0995
- Product name
- GSK1838705A
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $598
- Updated
- 2024/03/01
- Product number
- 24904
- Product name
- GSK1838705A
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 24904
- Product name
- GSK1838705A
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 24904
- Product name
- GSK1838705A
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $543
- Updated
- 2024/03/01
GSK1838705A Chemical Properties,Usage,Production
Uses
GSK 1838705 is a potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK).
Definition
ChEBI: 2-[[2-[[1-[2-(dimethylamino)-1-oxoethyl]-5-methoxy-2,3-dihydroindol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
Biological Activity
gsk1838705a is a small-molecule kinase inhibitor that inhibits igf-ir and the insulin receptor with ic50s of 2.0 and 1.6 nmol/l, respectively.igf-1r is a transmembrane receptor which is activated by insulin-like growth factor 1 and by a related hormone igf-2. this protein plays important role in the regulation of development. the insulin receptor is also a transmembrane receptor that is activated by insulin, igf-1 and igf2. this receptor is involved in insulin signaling pathway and plays an essential role in the regulation of glucose homeostasis.gsk1838705a obstructs the in vitro expansion of cell lines got from strong and hematologic malignancies, including numerous myeloma and ewing's sarcoma, and hinders the development of human tumor xenografts in vivo. in spite of the inhibitory impact of gsk1838705a on insulin receptor, insignificant effects on glucose homeostasis were seen at efficacious dosages. gsk1838705a represses the anaplastic lymphoma kinase (alk), which drives the distorted development of anaplastic substantial cell lymphomas, some neuroblastomas, and a subset of non–small cell lung growths.gsk1838705a restrains alk, with an ic50 value of 0.5 nm, furthermore, causes complete relapse of alk-ward tumors in vivo at very-endured measurements. gsk1838705a arrives for a promising antitumor agent for helpful use in human growth.
storage
Store at -20°C
References
[1]. sabbatini p, et al. gsk1838705a inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. mol cancer ther. 2009 oct;8(10):2811-20.
GSK1838705A Preparation Products And Raw materials
Raw materials
Preparation Products
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