AVP-AEW541
- Product Name
- AVP-AEW541
- CAS No.
- 475489-16-8
- Chemical Name
- AVP-AEW541
- Synonyms
- CS-470;AEW-541;NVP-AEW541;AVP-AEW541;NVP-AEW541cas;NVP-AEW541-NX;AEW541;NVP AEW541;NVP-AEW541(AEW541);AVP-AEW541 USP/EP/BP;AVP-AEW541 NVP-AEW541
- CBNumber
- CB32526059
- Molecular Formula
- C27H29N5O
- Formula Weight
- 439.55
- MOL File
- 475489-16-8.mol
AVP-AEW541 Property
- Melting point:
- 145℃
- Boiling point:
- 669.0±55.0 °C(Predicted)
- Density
- 1.33
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 9.59±0.10(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1973
- Product name
- NVP-AEW541
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $107.4
- Updated
- 2024/03/01
- Product number
- SML1973
- Product name
- NVP-AEW541
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $288
- Updated
- 2024/03/01
- Product number
- N925640
- Product name
- NVP-AEW541
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- N925640
- Product name
- NVP-AEW541
- Packaging
- 25mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- CS-0448
- Product name
- NVP-AEW541
- Purity
- >99.0%
- Packaging
- 50mg
- Price
- $540
- Updated
- 2021/12/16
AVP-AEW541 Chemical Properties,Usage,Production
Uses
NVP-AEW541 is insulin-like growth factor I receptor (IGF-IR) inhibitor.
Biological Activity
nvp-aew541 is a novel, potent and selective inhibitor of igf-ir kinase with ic50 value of 0.086 μm [1].nvp-aew541 is a pyrrolo(2,3-d) pyrimidine derivative. it has been reported to abolish igf-i-induced igf-ir autophosphorylation and to block the igf-ir signaling pathway mainly in ecc-1 and uspc-1 cancer cells. also in these cell lines, nvp-aew541 has been shown to change the igf-i induced cell cycle and to lead apoptotic cell death as well as exhibit antiproliferative effects [2]. in addition, it is observed that nvp-aew541 can induce radiosensitization in pten wild-type cell lines [3].
Biochem/physiol Actions
NVP-AEW541 is a reversible, ATP-competitive, orally available insulin-like growth factor-I receptor (IGF-IR, IGF-1R) inhibitor that, despite its equipotency against recombinant kinase domains of insulin receptor (InsR) and IGF-IR in cell-free kinase assays (IC50 = 140 & 150 nM, respectively), exhibits high selectivity toward cellular autophosphorylation of endogenous full-length IGF-1R (IC50 = 86 nM) over InsR (IC50 = 2.3 μM), HER1, PDGFR, c-Kit, and Bcr-Abl p210 (IC50 >5 μM). AEW541 effectively inhibits IGF-IR-mediated signaling and cancer survival (IC50 = 105 nM/MCF-7 soft agar growth, 1.64 μM/NWT-21 proliferation) in cultures and tumor growth in vivo (20 to 50 mg/kg twice daily p.o.; NWT-21 fibrosarcoma & TC-71 musculoskeletal sarcoma xenografts in mice).
target
IGF-IR kinase
References
[1] carlos garc a-echeverr a, mark a. pearson, andreas marti, thomas meyer, juergen mestan, johann zimmermann, jiaping gao, josef brueggen, hans-georg capraro, robert cozens, dean b. evans, doriano fabbro, pascal furet, diana graus porta, janis liebetanz, georg martiny-baron, stephan ruetz, and francesco hofmann. in vivo antitumor activity of nvp-aew541—a novel, potent, and selective inhibitor of the igf-ir kinase. cancer cell.2004 mar (5):231-239.
[2] zohar attias-geva, itay bentov, ami fishman, haim werner, ilan bruchim. insulin-like growth factor-i receptor inhibition by speci c tyrosine kinase inhibitor nvp-aew541 in endometrioid and serous papillary endometrial cancer cell lines. gynecologic oncology. 2011 feb (121):383-389.
[3] sofie f. isebaert, johannes v. swinnen, william h. mcbride, and karin m. haustermans. insulin-like growth factor–type 1 receptor inhibitor nvp-aew541 enhances radiosensitivity of pten wild-type but not pten-deficient human prostate cancer cells. international journal of radiation oncology biology physics. 2011 (81):239-247.
AVP-AEW541 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AVP-AEW541 manufacturers
- Product
- AVP-AEW541 475489-16-8
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08