AVP-AEW541

ChemicalBook > CAS DataBase List > AVP-AEW541

Product Name: AVP-AEW541
CAS No.: 475489-16-8
Chemical Name: AVP-AEW541
Synonyms: CS-470;AEW-541;NVP-AEW541;AVP-AEW541;NVP-AEW541cas;NVP-AEW541-NX;AEW541;NVP AEW541;NVP-AEW541(AEW541);AVP-AEW541 USP/EP/BP;AVP-AEW541 NVP-AEW541
CBNumber: CB32526059
Molecular Formula: C27H29N5O
Formula Weight: 439.55
MOL File: 475489-16-8.mol

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AVP-AEW541 Property

Melting point:: 145℃
Boiling point:: 669.0±55.0 °C(Predicted)
Density: 1.33
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 9.59±0.10(Predicted)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1973
Product name: NVP-AEW541
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1973
Product name: NVP-AEW541
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $288
Updated: 2024/03/01

TRC

Product number: N925640
Product name: NVP-AEW541
Packaging: 10mg
Price: $180
Updated: 2021/12/16

TRC

Product number: N925640
Product name: NVP-AEW541
Packaging: 25mg
Price: $375
Updated: 2021/12/16

ChemScene

Product number: CS-0448
Product name: NVP-AEW541
Purity: >99.0%
Packaging: 2mg
Price: $108
Updated: 2021/12/16

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AVP-AEW541 Chemical Properties,Usage,Production

Uses

NVP-AEW541 is insulin-like growth factor I receptor (IGF-IR) inhibitor.

Biological Activity

nvp-aew541 is a novel, potent and selective inhibitor of igf-ir kinase with ic50 value of 0.086 μm [1].nvp-aew541 is a pyrrolo(2,3-d) pyrimidine derivative. it has been reported to abolish igf-i-induced igf-ir autophosphorylation and to block the igf-ir signaling pathway mainly in ecc-1 and uspc-1 cancer cells. also in these cell lines, nvp-aew541 has been shown to change the igf-i induced cell cycle and to lead apoptotic cell death as well as exhibit antiproliferative effects [2]. in addition, it is observed that nvp-aew541 can induce radiosensitization in pten wild-type cell lines [3].

Biochem/physiol Actions

NVP-AEW541 is a reversible, ATP-competitive, orally available insulin-like growth factor-I receptor (IGF-IR, IGF-1R) inhibitor that, despite its equipotency against recombinant kinase domains of insulin receptor (InsR) and IGF-IR in cell-free kinase assays (IC50 = 140 & 150 nM, respectively), exhibits high selectivity toward cellular autophosphorylation of endogenous full-length IGF-1R (IC50 = 86 nM) over InsR (IC50 = 2.3 μM), HER1, PDGFR, c-Kit, and Bcr-Abl p210 (IC50 >5 μM). AEW541 effectively inhibits IGF-IR-mediated signaling and cancer survival (IC50 = 105 nM/MCF-7 soft agar growth, 1.64 μM/NWT-21 proliferation) in cultures and tumor growth in vivo (20 to 50 mg/kg twice daily p.o.; NWT-21 fibrosarcoma & TC-71 musculoskeletal sarcoma xenografts in mice).

target

IGF-IR kinase

References

[1] carlos garc a-echeverr a, mark a. pearson, andreas marti, thomas meyer, juergen mestan, johann zimmermann, jiaping gao, josef brueggen, hans-georg capraro, robert cozens, dean b. evans, doriano fabbro, pascal furet, diana graus porta, janis liebetanz, georg martiny-baron, stephan ruetz, and francesco hofmann. in vivo antitumor activity of nvp-aew541—a novel, potent, and selective inhibitor of the igf-ir kinase. cancer cell.2004 mar (5):231-239.
[2] zohar attias-geva, itay bentov, ami fishman, haim werner, ilan bruchim. insulin-like growth factor-i receptor inhibition by speci c tyrosine kinase inhibitor nvp-aew541 in endometrioid and serous papillary endometrial cancer cell lines. gynecologic oncology. 2011 feb (121):383-389.
[3] sofie f. isebaert, johannes v. swinnen, william h. mcbride, and karin m. haustermans. insulin-like growth factor–type 1 receptor inhibitor nvp-aew541 enhances radiosensitivity of pten wild-type but not pten-deficient human prostate cancer cells. international journal of radiation oncology biology physics. 2011 (81):239-247.

AVP-AEW541 Preparation Products And Raw materials

Raw materials

Preparation Products

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AVP-AEW541 Suppliers

China 84 United States 15 Global 99

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View Lastest Price from AVP-AEW541 manufacturers

Career Henan Chemical Co

Product: AVP-AEW541 475489-16-8
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

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[7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine

AVP-AEW541 NVP-AEW541

7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

[7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine AVP-AEW541

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7-((1s,3s)-3-(Azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimid

AVP-AEW541 USP/EP/BP

NVP-AEW541cas

AEW-541 cis-isomer (NVP-AEW541)

NVP-AEW541-NX

7-(cis-3-(Azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

475489-16-8

474589-16-8

Inhibitors