(R)-N-Boc-2-Hydroxymethylmorpholine

Product Name: (R)-N-Boc-2-Hydroxymethylmorpholine
CAS No.: 135065-71-3
Chemical Name: (R)-N-Boc-2-Hydroxymethylmorpholine
Synonyms: (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(R)-2-hydroxyMethyl-4-BOC-Morpholine;(R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(R)-N-Boc-2-hydroxymethylmorpholine,99%;(R)/(S)-N-Boc-2-hydroxymethylmorpholine;(R)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;(R)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine;Tert-Butyl(R)-2-(Hydroxymethyl)Morpholine-4-Carboxylate;(R)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH;tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate
CBNumber: CB2958329
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 135065-71-3.mol

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(R)-N-Boc-2-Hydroxymethylmorpholine Property

Melting point:: 59-61 °C
Boiling point:: 321 °C
Density: 1.118
Flash point:: 148 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.36±0.10(Predicted)
InChI: InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey: FJYBLMJHXRWDAQ-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCO[C@@H](CO)C1

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B600435
Product name: (R)-N-Boc-2-hydroxymethylmorpholine
Packaging: 1g
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: X9897
Product name: (R)-N-Boc-2-Hydroxymethylmorpholine
Packaging: 5g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43598
Product name: (R)-N-Boc-2-Hydroxymethylmorpholine
Packaging: 5G
Price: $100
Updated: 2021/12/16

Activate Scientific

Product number: AS12060
Product name: (R)-N-Boc-2-(hydroxymethyl)morpholine
Purity: 97+% ee
Packaging: 5G
Price: $107
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43598
Product name: (R)-N-Boc-2-Hydroxymethylmorpholine
Packaging: 2g
Price: $60
Updated: 2021/12/16

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(R)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties,Usage,Production

Uses

(R)-N-Boc-2-hydroxymethylmorpholine is used for preparation of inhibitors of Checkpoint Kinase 1 through template screening.

Synthesis

135097-68-6

135065-71-3

Intermediate 111 (19.8 g, 64.4 mmol) was stirred and reacted for 16 h under hydrogen atmosphere with 10% Pd/C (1.98 g, 1.86 mmol) as catalyst. Upon completion of the reaction, the catalyst was removed by vacuum filtration and the filtrate was concentrated under reduced pressure to afford 13.98 g (100% yield) of (R)-N-Boc-2-hydroxymethylmorpholine, the product was a colorless viscous oil that crystallized upon standing. The 1H NMR (250 MHz, chloroform-d) data of the product were as follows: δ [ppm] 3.98 - 3.75 (m, 3H), 3.73 - 3.41 (m, 4H), 3.03 - 2.83 (m, 1H), 2.82 - 2.65 (m, 1H), 2.12 (t, J = 5.9 Hz, 1H), 1.45 (s, 9H).

References

[1] Heterocycles, 1993, vol. 35, # 1, p. 105 - 109
[2] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 290
[3] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 112; 113-114
[4] Patent: US2010/184805, 2010, A1. Location in patent: Page/Page column 30-31
[5] Patent: WO2007/70201, 2007, A1. Location in patent: Page/Page column 176

(R)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-Boc-2-Hydroxymethylmorpholine Suppliers

China 219 Germany 1 India 2 United Kingdom 2 United States 14 Global 238

Shanghai KeLy Bio-Pharmaceutical Co., Ltd.

Tel: 13816253073
Email: lige@kelybiopharm.com
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ProdList: 122
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Doly Chemical CO.,LTD.

Tel: 021-34716221 15800796336
Fax: +86-21-31329566
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ProdList: 289
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
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Country: China
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Lianhe Aigen Pharmatech Co.,Ltd.

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Chengdu Dorher Pharmaceutical CO.,Ltd

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Country: China
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Anhui Nature Pharmaceutical Co., Ltd.

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MINKESH (SHANGHAI) CO., LTD.

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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
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View Lastest Price from (R)-N-Boc-2-Hydroxymethylmorpholine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-N-Boc-2-Hydroxymethylmorpholine 135065-71-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Honest Joy Holdings Limited

Product: (R)-N-Boc-2-hydroxymethylmorpholine 135065-71-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.1%
Supply Ability: 100 tons
Release date: 2022-01-25

Career Henan Chemical Co

Product: (R)-N-Boc-2-Hydroxymethylmorpholine 135065-71-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

135065-71-3, (R)-N-Boc-2-HydroxymethylmorpholineRelated Search:

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(R)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

(R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE

(R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE

tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate

(R)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine

2-(Hydroxymethyl)morpholine-4-carboxylic acid (R)-tert-butyl ester

4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester, (2R)-

(R)-2-hydroxyMethyl-4-BOC-Morpholine

(2R)-2-(Hydroxymethyl)-4-morpholinecarboxylic acid tert-butyl ester

(R)-N-Boc-2-hydroxymethylmorpholine,99%e.e.

Tert-Butyl(R)-2-(Hydroxymethyl)Morpholine-4-Carboxylate

tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate 95+%

(R)-N-Boc-2-hydroxymethylmorpholine,99%

(R)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH

(R)/(S)-N-Boc-2-hydroxymethylmorpholine

135065-71-3

pharmacetical