MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER

Product Name: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
CAS No.: 212650-43-6
Chemical Name: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
Synonyms: 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID;4-Boc-morpholine-3-carboxylic acid;(R/S)-BOC-3-CARBOXYMORPHOLINE;4-Boc-3-morpholinecarboxylic acid;N-Boc-morpholine-3-carboxylic acid;N-Boc-Morpholine-2-carboxylic acid;4-N-BOC-3-MORPHOLINECARBOXYLIC ACID;4-N-Boc-Morpholine-3-carboxylic acid;Morpholine-3,4-dicarboxylic acid 4-tert-butyl;4-tert-Butoxymethyl-morpholine-3-carboxylic acid
CBNumber: CB3739349
Molecular Formula: C10H17NO5
Formula Weight: 231.25
MOL File: 212650-43-6.mol

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MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Property

Boiling point:: 369℃
Density: 1.230
Flash point:: 177℃
storage temp.: 2-8°C
pka: 3.53±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
InChIKey: KVXXEKIGMOEPSA-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCOCC1C(O)=O
CAS DataBase Reference: 212650-43-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-51-36
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B699573
Product name: 4-(tert-Butoxycarbonyl)morpholine-3-carboxylicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143016
Product name: 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid
Packaging: 250mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-M0709
Product name: 4-(tert-butoxycarbonyl)morpholine-3-carboxylicacid
Purity: ≥97.0%
Packaging: 1g
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143016
Product name: 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid
Packaging: 500mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: W4426
Product name: 4-Boc-3-morpholinecarboxylicacid
Packaging: 1g
Price: $137
Updated: 2021/12/16

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MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester is an organic heterocyclic compound that can be used in decarboxylation arylation reactions to prepare other compounds. It is also used as a synthetic intermediate component in the preparation of substances such as thienopyrrole compounds, pyridine derivatives and cyclised acetamide derivatives.

Synthesis

77873-76-8

24424-99-5

212650-43-6

The general procedure for the synthesis of 4-Boc-3-morpholinecarboxylic acid from 3-morpholinecarboxylic acid and di-tert-butyl dicarbonate is as follows: di-tert-butyl dicarbonate (3.33 g, 15.3 mmol) was slowly added to acetone (5 mL) and water (0 mL) containing morpholine-3-carboxylic acid (1.7 g, 10.2 mmol), potassium carbonate (7.04 g, 51 mmol) in a 0°C in a mixed solution. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction solution was diluted with water (50 mL) and extracted with ether (2 x 50 mL). The aqueous phase was acidified with 2M aqueous hydrochloric acid (100 mL) and then extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the white solid product 4-Boc-3-morpholinecarboxylic acid (1.98 g, 84% yield). The product was characterized by 1H NMR (CDCl3), δ (ppm): 4.46 (m, 2H), 3.80 (m, 3H), 3.53 (m, 1H), 3.31 (m, 1H), 1.48 (d, 9H).

References

[1] Patent: WO2005/80386, 2005, A1. Location in patent: Page/Page column 40
[2] Angewandte Chemie - International Edition, 2018,
[3] Angew. Chem., 2018, vol. 130, # 44, p. 14768 - 14773,6
[4] Patent: WO2009/67233, 2009, A1. Location in patent: Page/Page column 46-47

MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Sodium hypochlorite Ethanol Potassium bromide Acetone Toluene Di-tert-butyl dicarbonate Sodium bis(2-methoxyethoxy)aluminiumhydride Sodium borohydride Triethylamine Palladium Chloroacetyl chloride TEMPO Benzaldehyde DL-Serine Sodium bicarbonate Methanol Sodium hydroxide

Preparation Products

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MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Suppliers

Canada 1 China 140 France 1 Germany 4 India 3 United Kingdom 5 United States 15 Global 169

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View Lastest Price from MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 212650-43-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-11

Career Henan Chemical Co

Product: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 212650-43-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

212650-43-6, MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTERRelated Search:

N-T-BOC-PYRROLE 1-BOC-2,3-DIHYDRO-7-INDOLECARBALDEHYDE tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 4-Boc-3(S)-morpholinecarboxylic acid MORPHOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE (S)-Morpholine-3-carboxylic acid HCl (R)-3-MORPHOLINECARBOXYLIC ACID HCL (S)-3-MORPHOLINECARBOXYLIC ACID HCL (R)-Morpholine-3-carboxylic acid HCl 3-Morpholinecarboxylic acid 4-Boc-3(R)-morpholinecarboxylic acid N-BOC-INDOLINE-7-CARBOXYLIC ACID (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid (S)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER (S)-MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 3-METHYL ESTER (S)-4-BOC-6,6-DIMETHYL-MORPHOLINE-3-CARBOXYLIC ACID

MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER

(S)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl

Morpholine-3,4-dicarboxylic acid 4-tert-butyl

4-N-BOC-3-MORPHOLINECARBOXYLIC ACID

4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID

N-Boc-Morpholine-2-carboxylic acid

N-Boc-morpholine-3-carboxylic acid

4-Boc-3-morpholinecarboxylic acid

3,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester

Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester ,97%

4-[[(1,1-Dimethylethyl)oxy]carbonyl]-3-morpholinecarboxylic acid

4-N-Boc-Morpholine-3-carboxylic acid

(R/S)-BOC-3-CARBOXYMORPHOLINE

4-Boc-morpholine-3-carboxylic acid

4-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]MORPHOLINE-3-CARBOXYLIC ACID

4-tert-Butoxymethyl-morpholine-3-carboxylic acid

Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester, CAS 212650-43-6

212650-43-6

pharmacetical