tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Product Name: tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.: 143557-91-9
Chemical Name: tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Synonyms: N-Boc-Nortropine;N-Boc-Desmethyltropine;N-tert-Butoxycarbonylnortropan-3-ol;8-(tert-Butoxycarbonyl)-3-alpha-nortropanol;endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;(3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CBNumber: CB32129362
Molecular Formula: C12H21NO3
Formula Weight: 227.3
MOL File: 143557-91-9.mol

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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Property

Melting point:: 141.5℃
Boiling point:: 328℃
Density: 1.146
Flash point:: 152℃
storage temp.: 2-8°C
pka: 14.79±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1/C12H21NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-10,14H,4-7H2,1-3H3/t8-,9?,10+/s3
InChIKey: SEGZJJSZYOEABC-RHMQUPMUNA-N
SMILES: C(=O)(OC(C)(C)C)N1[C@H]2CCC1C[C@H](O)C2 |&1:8,13,r|

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Safety

Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
RIDADR: UN2811
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR950059
Product name: tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity: 97%
Packaging: 1g
Price: $15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-LH
Product name: endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
Packaging: 1g
Price: $24
Updated: 2021/12/16

Apolloscientific

Product number: OR950059
Product name: tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity: 97%
Packaging: 5g
Price: $40
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-LH
Product name: endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
Packaging: 5G
Price: $64
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140344
Product name: tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Packaging: 2g
Price: $80
Updated: 2021/12/16

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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

538-09-0

143557-91-9

General procedure for the synthesis of tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate from di-tert-butyl dicarbonate and endo-8-azabicyclo[3.2.1]octan-3-ol: endo-8-azabicyclo[3.2.1]octan-3-ol (3.6 g, 28.3 mmol) was dissolved in dichloromethane (50 mL) and the solution was cooled to 0°C. Triethylamine (7.8 mL, 56.7 mmol) and di-tert-butyl dicarbonate (7.4 g, 33.9 mmol) were added sequentially with stirring. The reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. After completion of the reaction, the reaction mixture was diluted with distilled water. The organic layer was separated and washed sequentially with saturated aqueous citric acid solution, distilled water and saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate as a white solid (6.45 g, 28.4 mmol, 100% yield). Mass spectrum (ESI) m/z: 228 [M + H]+.

References

[1] Patent: WO2007/63071, 2007, A1. Location in patent: Page/Page column 15
[2] Patent: US2007/123525, 2007, A1. Location in patent: Page/Page column 20
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 210; 211
[4] Patent: WO2014/152144, 2014, A1. Location in patent: Paragraph 0190
[5] Patent: WO2009/106534, 2009, A1. Location in patent: Page/Page column 73

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Suppliers

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View Lastest Price from tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate manufacturers

Shanghai Rlavie Technology Co ltd

Product: N-Boc-Nortropine 143557-91-9
Price: US $0.00-0.00/kg
Min. Order: 0.001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-09

Career Henan Chemical Co

Product: tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 143557-91-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

143557-91-9, tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylateRelated Search:

Nortropine hydrochloride Nortropine GRANISETRON IMPURITY B tert-butyl endo-3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate N-BOC-INDOLINE-7-CARBOXYLIC ACID N-T-BOC-PYRROLE MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-BOC-2,3-DIHYDRO-7-INDOLECARBALDEHYDE TERT-BUTYL FORMATE tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3-endo)-

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

N-Boc-Nortropine

endo-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid 1,1-dimethylethyl ester

N-tert-Butoxycarbonylnortropan-3-ol

endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane

tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

tert-butyl (1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane

(3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane

rel-tert-butyl (1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

N-Boc-Desmethyltropine

8-(tert-Butoxycarbonyl)-3-alpha-nortropanol

tert-butyl Rel-(1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

143557-91-9