ChemicalBook > CAS DataBase List > tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

Product Name
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.
143557-91-9
Chemical Name
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Synonyms
N-Boc-Nortropine;N-Boc-Desmethyltropine;N-tert-Butoxycarbonylnortropan-3-ol;8-(tert-Butoxycarbonyl)-3-alpha-nortropanol;endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;(3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane;tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate;tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
CBNumber
CB32129362
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
143557-91-9.mol
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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Property

Melting point:
141.5℃
Boiling point:
328℃
Density 
1.146
Flash point:
152℃
storage temp. 
2-8°C
pka
14.79±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1/C12H21NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-10,14H,4-7H2,1-3H3/t8-,9?,10+/s3
InChIKey
SEGZJJSZYOEABC-RHMQUPMUNA-N
SMILES
C(=O)(OC(C)(C)C)N1[C@H]2CCC1C[C@H](O)C2 |&1:8,13,r|
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Safety

Risk Statements 
22-36/37/38
Safety Statements 
22-26-36/37/39
RIDADR 
UN2811
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
OR950059
Product name
tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity
97%
Packaging
1g
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-LH
Product name
endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
Packaging
1g
Price
$24
Updated
2021/12/16
Apolloscientific
Product number
OR950059
Product name
tert-Butyl3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Purity
97%
Packaging
5g
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-LH
Product name
endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
Packaging
5G
Price
$64
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140344
Product name
tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Packaging
2g
Price
$80
Updated
2021/12/16
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tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

538-09-0

143557-91-9

General procedure for the synthesis of tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate from di-tert-butyl dicarbonate and endo-8-azabicyclo[3.2.1]octan-3-ol: endo-8-azabicyclo[3.2.1]octan-3-ol (3.6 g, 28.3 mmol) was dissolved in dichloromethane (50 mL) and the solution was cooled to 0°C. Triethylamine (7.8 mL, 56.7 mmol) and di-tert-butyl dicarbonate (7.4 g, 33.9 mmol) were added sequentially with stirring. The reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. After completion of the reaction, the reaction mixture was diluted with distilled water. The organic layer was separated and washed sequentially with saturated aqueous citric acid solution, distilled water and saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford tert-butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate as a white solid (6.45 g, 28.4 mmol, 100% yield). Mass spectrum (ESI) m/z: 228 [M + H]+.

References

[1] Patent: WO2007/63071, 2007, A1. Location in patent: Page/Page column 15
[2] Patent: US2007/123525, 2007, A1. Location in patent: Page/Page column 20
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 210; 211
[4] Patent: WO2014/152144, 2014, A1. Location in patent: Paragraph 0190
[5] Patent: WO2009/106534, 2009, A1. Location in patent: Page/Page column 73

tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate manufacturers

Shanghai Rlavie Technology Co ltd
Product
N-Boc-Nortropine 143557-91-9
Price
US $0.00-0.00/kg
Min. Order
0.001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-09
Career Henan Chemical Co
Product
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 143557-91-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

143557-91-9, tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylateRelated Search:

Nortropine hydrochloride Nortropine GRANISETRON IMPURITY B tert-butyl endo-3-amino-9-azabicyclo[3.3.1]nonane-9-carboxylate N-BOC-INDOLINE-7-CARBOXYLIC ACID N-T-BOC-PYRROLE MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 1-BOC-2,3-DIHYDRO-7-INDOLECARBALDEHYDE TERT-BUTYL FORMATE tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

  • 8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3-endo)-
  • tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • N-Boc-Nortropine
  • endo-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid 1,1-dimethylethyl ester
  • N-tert-Butoxycarbonylnortropan-3-ol
  • endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
  • tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • (3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
  • tert-butyl (1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
  • (3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
  • rel-tert-butyl (1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • tert-butyl endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • N-Boc-Desmethyltropine
  • 8-(tert-Butoxycarbonyl)-3-alpha-nortropanol
  • tert-butyl Rel-(1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
  • 143557-91-9