MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
- Product Name
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
- CAS No.
- 212650-43-6
- Chemical Name
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
- Synonyms
- 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID;4-Boc-morpholine-3-carboxylic acid;(R/S)-BOC-3-CARBOXYMORPHOLINE;4-Boc-3-morpholinecarboxylic acid;N-Boc-morpholine-3-carboxylic acid;N-Boc-Morpholine-2-carboxylic acid;4-N-BOC-3-MORPHOLINECARBOXYLIC ACID;4-N-Boc-Morpholine-3-carboxylic acid;Morpholine-3,4-dicarboxylic acid 4-tert-butyl;4-tert-Butoxymethyl-morpholine-3-carboxylic acid
- CBNumber
- CB3739349
- Molecular Formula
- C10H17NO5
- Formula Weight
- 231.25
- MOL File
- 212650-43-6.mol
MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Property
- Boiling point:
- 369℃
- Density
- 1.230
- Flash point:
- 177℃
- storage temp.
- 2-8°C
- pka
- 3.53±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
- InChIKey
- KVXXEKIGMOEPSA-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCOCC1C(O)=O
- CAS DataBase Reference
- 212650-43-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-51-36
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B699573
- Product name
- 4-(tert-Butoxycarbonyl)morpholine-3-carboxylicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-M0709
- Product name
- 4-(tert-butoxycarbonyl)morpholine-3-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FB143016
- Product name
- 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB143016
- Product name
- 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- W4426
- Product name
- 4-Boc-3-morpholinecarboxylicacid
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester is an organic heterocyclic compound that can be used in decarboxylation arylation reactions to prepare other compounds. It is also used as a synthetic intermediate component in the preparation of substances such as thienopyrrole compounds, pyridine derivatives and cyclised acetamide derivatives.
Synthesis
77873-76-8
24424-99-5
212650-43-6
The general procedure for the synthesis of 4-Boc-3-morpholinecarboxylic acid from 3-morpholinecarboxylic acid and di-tert-butyl dicarbonate is as follows: di-tert-butyl dicarbonate (3.33 g, 15.3 mmol) was slowly added to acetone (5 mL) and water (0 mL) containing morpholine-3-carboxylic acid (1.7 g, 10.2 mmol), potassium carbonate (7.04 g, 51 mmol) in a 0°C in a mixed solution. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction solution was diluted with water (50 mL) and extracted with ether (2 x 50 mL). The aqueous phase was acidified with 2M aqueous hydrochloric acid (100 mL) and then extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the white solid product 4-Boc-3-morpholinecarboxylic acid (1.98 g, 84% yield). The product was characterized by 1H NMR (CDCl3), δ (ppm): 4.46 (m, 2H), 3.80 (m, 3H), 3.53 (m, 1H), 3.31 (m, 1H), 1.48 (d, 9H).
References
[1] Patent: WO2005/80386, 2005, A1. Location in patent: Page/Page column 40
[2] Angewandte Chemie - International Edition, 2018,
[3] Angew. Chem., 2018, vol. 130, # 44, p. 14768 - 14773,6
[4] Patent: WO2009/67233, 2009, A1. Location in patent: Page/Page column 46-47
MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER Suppliers
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- 021-31261262/ 49 (0)17662837245
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- Germany
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View Lastest Price from MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER manufacturers
- Product
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 212650-43-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-11
- Product
- MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER 212650-43-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24