4-Boc-3(S)-morpholinecarboxylic acid

Product Name: 4-Boc-3(S)-morpholinecarboxylic acid
CAS No.: 783350-37-8
Chemical Name: 4-Boc-3(S)-morpholinecarboxylic acid
Synonyms: S-4-boc-morphine-3-carboxylic acid;4-Boc-3(S)-morpholinecarboxylic acid;(S)-N-Boc-morpholine-3-carboxylic acid;(S)-4-N-Boc-3-Morpholinecarboxylic acid;(S)-4-N-Boc-Morpholine-3-carboxylic acid;4-(tert-Butoxycarbonyl)morpholine-3-(S)-carboxylic acid;(S)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester;(3S)-4-[(tert-butoxy)carbonyl]Morpholine-3-carboxylic acid;(3S)-3,4-Morpholinedicarboxylic Acid 4-(1,1- Dimethylethyl) Ester;3,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester, (3S)-
CBNumber: CB21119433
Molecular Formula: C10H17NO5
Formula Weight: 231.25
MOL File: 783350-37-8.mol

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4-Boc-3(S)-morpholinecarboxylic acid Property

Boiling point:: 369.5±42.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 3.53±0.20(Predicted)
form: powder
color: White
optical activity: Consistent with structure
InChI: InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
InChIKey: KVXXEKIGMOEPSA-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCOC[C@H]1C(O)=O

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B657235
Product name: (S)-4-Boc-morpholine-3-carboxylicAcid
Packaging: 250mg
Price: $85
Updated: 2021/12/16

TRC

Product number: B657235
Product name: (S)-4-Boc-morpholine-3-carboxylicAcid
Packaging: 1g
Price: $195
Updated: 2021/12/16

TRC

Product number: B657235
Product name: (S)-4-Boc-morpholine-3-carboxylicAcid
Packaging: 5g
Price: $580
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56336
Product name: (S)-4-Boc-morpholine-3-carboxylic acid
Packaging: 5G
Price: $625
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37602
Product name: 4-Boc-3(S)-morpholinecarboxylicacid
Packaging: 1g
Price: $435
Updated: 2021/12/16

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4-Boc-3(S)-morpholinecarboxylic acid Chemical Properties,Usage,Production

Uses

(S)-4-Boc-morpholine-3-carboxylic Acid is used to prepare indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.

Synthesis

77873-76-8

24424-99-5

783350-37-8

The general procedure for the synthesis of (3S)-4-tert-butyl 3,4-morpholine dicarboxylate from 3-morpholinecarboxylic acid and di-tert-butyl dicarbonate was as follows: to a solution of dichloromethane (DCM, 100 mL) containing morpholine-3-carboxylic acid (3 g, 22.9 mmol, 1.0 eq.) was added sequentially triethylamine (TEA, 6.9 g, 68.7 mmol, 3.0 eq.) and di Di-tert-butyl carbonate (Boc2O, 15 g, 68.7 mmol, 3.0 eq.). The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated and the resulting residue was purified by silica gel column chromatography (eluent ratio petroleum ether/ethyl acetate = 5/1) to afford the target product (S)-4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid (700 mg, 14% yield) as a colorless liquid.

References

[1] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00266

4-Boc-3(S)-morpholinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Boc-3(S)-morpholinecarboxylic acid Suppliers

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View Lastest Price from 4-Boc-3(S)-morpholinecarboxylic acid manufacturers

Career Henan Chemical Co

Product: 4-Boc-3(S)-morpholinecarboxylic acid 783350-37-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

783350-37-8, 4-Boc-3(S)-morpholinecarboxylic acidRelated Search:

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(S)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

4-(tert-Butoxycarbonyl)morpholine-3-(S)-carboxylic acid

4-Boc-3(S)-morpholinecarboxylic acid

3,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester, (3S)-

(3S)-4-[(tert-butoxy)carbonyl]Morpholine-3-carboxylic acid

(S)-4-N-Boc-3-Morpholinecarboxylic acid

(3S)-3,4-Morpholinedicarboxylic Acid 4-(1,1- Dimethylethyl) Ester

(3S)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid

(3S)-3,4-Morpholinedicarboxylic Acid 4-(1,1-Dimethylethyl) Ester,99%e.e.

(S)-4-N-Boc-Morpholine-3-carboxylic acid

(S)-N-Boc-morpholine-3-carboxylic acid

S-4-boc-morphine-3-carboxylic acid

783350-37-8