tert-Butyl chloroacetate
- Product Name
- tert-Butyl chloroacetate
- CAS No.
- 107-59-5
- Chemical Name
- tert-Butyl chloroacetate
- Synonyms
- 153N-6;NSC 87891;ClCH2C(O)OC(CH3)3;(10E)-3-O-De(αtert-Butyl chloroace;T-BUTYL CHLOROACETATE;TERT-BUTYL CHLORACETATE;3-Formyl Tyrosol αreft-Butyl chloroacetate;TERT-BUTYL CHLOROACETATE
- CBNumber
- CB7749461
- Molecular Formula
- C6H11ClO2
- Formula Weight
- 150.6
- MOL File
- 107-59-5.mol
tert-Butyl chloroacetate Property
- Boiling point:
- 48-49 °C/11 mmHg (lit.)
- Density
- 1.053 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.423(lit.)
- Flash point:
- 116 °F
- storage temp.
- Flammables area
- form
- Liquid
- Specific Gravity
- 1.053
- color
- Clear colorless to yellow
- Water Solubility
- <0.1 g/L (20 ºC)
- Merck
- 14,1563
- BRN
- 1753006
- LogP
- 2.07
- CAS DataBase Reference
- 107-59-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, chloro-, 1,1-dimethylethyl ester(107-59-5)
- EPA Substance Registry System
- Acetic acid, chloro-, 1,1-dimethylethyl ester (107-59-5)
Safety
- Hazard Codes
- C,N,Xn,Xi,F
- Risk Statements
- 20/21/22-34-50/53-36/37/38-10
- Safety Statements
- 26-36/37/39-45-61-60-16-7/9
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 3
- RTECS
- AF8985500
- F
- 19-21
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29154000
- Toxicity
- rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 186791
- Product name
- tert-Butyl chloroacetate
- Purity
- 97%
- Packaging
- 25g
- Price
- $46.8
- Updated
- 2024/03/01
- Product number
- 186791
- Product name
- tert-Butyl chloroacetate
- Purity
- 97%
- Packaging
- 100g
- Price
- $83.2
- Updated
- 2024/03/01
- Product number
- C1267
- Product name
- tert-Butyl Chloroacetate
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $33
- Updated
- 2024/03/01
- Product number
- C1267
- Product name
- tert-Butyl Chloroacetate
- Purity
- >97.0%(GC)
- Packaging
- 500mL
- Price
- $94
- Updated
- 2024/03/01
- Product number
- A15833
- Product name
- tert-Butyl chloroacetate, 98%
- Packaging
- 25g
- Price
- $26.65
- Updated
- 2024/03/01
tert-Butyl chloroacetate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.
Uses
tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.
Uses
In the glycidic ester condensation.
Preparation
tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.
Safety Profile
A poison by ingestion. Moderately toxic by inhalation skin contact. S severe sluin and moderate eye irritant. When heated to decomposition it emits toxic vapors of Cl-.
Purification Methods
Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]
tert-Butyl chloroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl chloroacetate manufacturers
- Product
- tert-Butyl chloroacetate 107-59-5
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2023-05-16
- Product
- tert-Butyl chloroacetate 107-59-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.985
- Supply Ability
- 20tons
- Release date
- 2023-10-13
- Product
- tert-Butyl chloroacetate 107-59-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-18