tert-Butyl chloroacetate

Product Name: tert-Butyl chloroacetate
CAS No.: 107-59-5
Chemical Name: tert-Butyl chloroacetate
Synonyms: 153N-6;NSC 87891;ClCH2C(O)OC(CH3)3;(10E)-3-O-De(αtert-Butyl chloroace;T-BUTYL CHLOROACETATE;TERT-BUTYL CHLORACETATE;3-Formyl Tyrosol αreft-Butyl chloroacetate;TERT-BUTYL CHLOROACETATE
CBNumber: CB7749461
Molecular Formula: C6H11ClO2
Formula Weight: 150.6
MOL File: 107-59-5.mol

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tert-Butyl chloroacetate Property

Boiling point:: 48-49 °C/11 mmHg (lit.)
Density: 1.053 g/mL at 25 °C (lit.)
refractive index: n20/D 1.423(lit.)
Flash point:: 116 °F
storage temp.: Flammables area
form: Liquid
Specific Gravity: 1.053
color: Clear colorless to yellow
Water Solubility: <0.1 g/L (20 ºC)
Merck: 14,1563
BRN: 1753006
LogP: 2.07
CAS DataBase Reference: 107-59-5(CAS DataBase Reference)
NIST Chemistry Reference: Acetic acid, chloro-, 1,1-dimethylethyl ester(107-59-5)
EPA Substance Registry System: Acetic acid, chloro-, 1,1-dimethylethyl ester (107-59-5)

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Safety

Hazard Codes: C,N,Xn,Xi,F
Risk Statements: 20/21/22-34-50/53-36/37/38-10
Safety Statements: 26-36/37/39-45-61-60-16-7/9
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
RTECS: AF8985500
F: 19-21
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29154000
Toxicity: rat,LC50,inhalation,4738mg/m3/4H (4738mg/m3),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMOR,International Journal of Toxicology. Vol. 19, Pg. 333, 2000.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 186791
Product name: tert-Butyl chloroacetate
Purity: 97%
Packaging: 25g
Price: $46.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 186791
Product name: tert-Butyl chloroacetate
Purity: 97%
Packaging: 100g
Price: $83.2
Updated: 2024/03/01

TCI Chemical

Product number: C1267
Product name: tert-Butyl Chloroacetate
Purity: >97.0%(GC)
Packaging: 25mL
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: C1267
Product name: tert-Butyl Chloroacetate
Purity: >97.0%(GC)
Packaging: 500mL
Price: $94
Updated: 2024/03/01

Alfa Aesar

Product number: A15833
Product name: tert-Butyl chloroacetate, 98%
Packaging: 25g
Price: $26.65
Updated: 2024/03/01

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tert-Butyl chloroacetate Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellow liquid. Hydrolysis generates tert-butanol and chloroacetic acid.

Uses

tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.

Uses

In the glycidic ester condensation.

Preparation

tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%.

Safety Profile

A poison by ingestion. Moderately toxic by inhalation skin contact. S severe sluin and moderate eye irritant. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.]

tert-Butyl chloroacetate Preparation Products And Raw materials

Raw materials

Chloroacetyl chloride

Preparation Products

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tert-Butyl chloroacetate Suppliers

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View Lastest Price from tert-Butyl chloroacetate manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: tert-Butyl chloroacetate 107-59-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.985
Supply Ability: 20tons
Release date: 2023-10-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tert-Butyl Chloroacetate 107-59-5
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-22

Hebei Mojin Biotechnology Co., Ltd

Product: tert-Butyl chloroacetate 107-59-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-18

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Acetic acid, chloro-, tert-butyl ester

aceticacid,chloro-,1,1-dimethylethylester

ClCH2C(O)OC(CH3)3

tert-Butyl chloroacetate,97%

tert-Butyl chloroacetate,99%

tert-Butyl chloroace

tert-Butyl chloroacetate, 97% 100GR

NSC 87891

ChloroaceticAcidtert-ButylEste

(InterMediate of Tert-Butyl Rosuvastatin)

Aceticacid, 2-chloro-, 1,1-diMethylethyl ester

Tert butyl chloro acetic acid

-L-cladinose)-10-dehydro-11-dehydroxy-6-O-methyl-erythromycin

153N-6

Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 MPFRWFKPV-NH2

MET-PRO-D-PHE-ARG-D-TRP-PHE-LYS-PRO-VAL-NH2MPFRWFKPV-NH2;153N-6;L-METHIONYL-L-PROLYL-D-PHENYLALANYL-L-ARGINYL-D-TRYPTOPHYL-L-PHENYLALANYL-L-LYSYL-L-PROLYL-L-VALINAMIDE; ACETATE

tert-Butyl chloroacetate, 98+%

1,1-Dimethylethyl chloroacetate

Chloroacetic acid 1,1-dimethylethyl ester

Chloroacetic acid 1,1-dimethylethyl

reft-Butyl chloroacetate

T-BUTYL CHLOROACETATE

TERT-BUTYL CHLORACETATE

TERT-BUTYL CHLOROACETATE

CHLOROACETIC ACID T-BUTYL ESTER

CHLOROACETIC ACID TERT-BUTYL ESTER

#ntert.-Butyl chloroacetate

1,4-Dimethyl-5H-pyrido[4,3-β]indol-3-amine-13C,15N Monoacetate

3-Amino-1,4-dimethyl-5h-pyrido[4,3-β]indole-13C2,15N Acetate

3-Formyl Tyrosol &alpha

4-O-Benzyl-3-acetyloxy Tyrosol &alpha

(10E)-3-O-De(&alpha

tert-Butyl Chloroacetate &gt

107-59-5 (TERT-BUTYL CHLOROACETATE)

tert-Butyl Chloroacetate, ≥ 97.0%

107-59-5

54512-75-2

C1313C2H17N215NO2

C6H11ClO2

ClCH2CO2CCH33

ACETATE

Esters

Organic Building Blocks

C6 to C7

Carbonyl Compounds

Building Blocks

Pharmaceutical intermediates

API Intermediate

API intermediates

C6 to C7

Carbonyl Compounds

Esters

K00001