(S)-N-Boc-2-Hydroxymethylmorpholine

Product Name: (S)-N-Boc-2-Hydroxymethylmorpholine
CAS No.: 135065-76-8
Chemical Name: (S)-N-Boc-2-Hydroxymethylmorpholine
Synonyms: 135065-76-8;(S)-N-Boc-2-HydroxyMethyl...;N-Boc-(S)-3-morpholine-methanol;(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(S)-2-hydroxyMethyl-4-BOC-Morpholine;(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol;(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected;(S)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine
CBNumber: CB3958331
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 135065-76-8.mol

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(S)-N-Boc-2-Hydroxymethylmorpholine Property

Melting point:: 60-62 °C
Boiling point:: 321 °C
Density: 1.118
Flash point:: 148 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.36±0.10(Predicted)
form: solid
color: White
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
InChI: InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey: FJYBLMJHXRWDAQ-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCO[C@H](CO)C1
CAS DataBase Reference: 135065-76-8

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: S960028
Product name: (S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W003598
Product name: (S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Purity: ≥97.0%
Packaging: 10g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: X9898
Product name: (S)-N-Boc-(2-Hydroxymethyl)morpholine
Packaging: 1g
Price: $74
Updated: 2021/12/16

ChemScene

Product number: CS-W003598
Product name: (S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Purity: ≥97.0%
Packaging: 1g
Price: $16
Updated: 2021/12/16

Activate Scientific

Product number: AS12059
Product name: (S)-N-Boc-morpholine-2-methanol
Purity: 97+% ee
Packaging: 1g
Price: $41
Updated: 2021/12/16

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(S)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties,Usage,Production

Uses

(S)-N-Boc-2-hydroxymethylmorpholine is used as a pharmaceutical intermediate.

Synthesis

911223-10-4

135065-76-8

Under stirring conditions, (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate (5.27 g, 17.2 mmol) was dissolved in 200 mL of ethanol, followed by the addition of 0.527 g of palladium/activated carbon catalyst and two drops of 1N hydrochloric acid. The reaction system was replaced three times with hydrogen and then reacted overnight at 70 °C under hydrogen atmosphere, and the reaction progress was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with 100 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate (200 mL × 4). The organic phases were combined, washed sequentially with 100 mL of water and 100 mL of saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford (S)-N-Boc-2-hydroxymethylmorpholine (3.646 g, 97.7% yield) as colorless to light yellow liquid. Mass spectrum (ESI) m/z: 240.3 [M + 23]. 1H NMR (CDCl3, 400 MHz) δ 3.92-3.88 (m, 3H), 3.7-3.64 (m, 1H), 3.60-3.48 (m, 3H), 2.936 (m, 1H), 2.75 (m, 1H), 2.06 (m, 1H), 1.46 (s , 9H).

References

[1] Patent: EP2189451, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2010/210640, 2010, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35
[4] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[5] Patent: WO2006/105262, 2006, A1. Location in patent: Page/Page column 74; 75

(S)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-Boc-2-Hydroxymethylmorpholine Suppliers

China 181 India 1 United Kingdom 1 United States 12 Global 195

Deyang Chengchuang Pharmaceutical Technology Co., Ltd.

Tel: 028-66569636 18227172063
Fax: 028-66569636
Email: sales@dyccpharma.com
Country: China
ProdList: 49
Advantage: 58

Chengdu Focus Pharmaceutical Technology Co., Ltd.

Tel: 028-64950838 17340131597
Email: bd-focus@focuspharm.com
Country: China
ProdList: 850
Advantage: 58

Shanghai KeLy Bio-Pharmaceutical Co., Ltd.

Tel: 13816253073
Email: lige@kelybiopharm.com
Country: China
ProdList: 122
Advantage: 58

Changsha Qisheng Heyan Medical Technology Co., LTD

Tel: 18684929597
Email: 527907673@qq.com
Country: China
ProdList: 103
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
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View Lastest Price from (S)-N-Boc-2-Hydroxymethylmorpholine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8
Price: US $0.01/Kg/Drum
Min. Order: 1g
Purity: 99%+
Supply Ability: 100T
Release date: 2019-12-24

Career Henan Chemical Co

Product: (S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

135065-76-8, (S)-N-Boc-2-HydroxymethylmorpholineRelated Search:

BUTYL OLEATE Butyl acetate Cyhalofop-butyl Moroxydine hydrochloride tert-Butyl peroxyacetate tert-Butyl acetate Buprofezin Tridemorph tert-Butanol Dimethomorph Moroxydine Tris(trimethylsilyl)phosphate (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (S)-N-Boc-2-aminomethylmorpholine (S)-1-Boc-2-(Hydroxymethyl)piperazine 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate

(S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

N-Boc-(S)-3-morpholine-methanol

(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE

(2S)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester

(S)-N-Boc-2-HydroxyMethyl...

(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE

tert-Butyl (2S)-2-(hydroxyMethyl)Morpholine-4-carboxylate

4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester, (2S)-

(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected

tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate, (2S)-4-(tert-Butoxycarbonyl)-2-(hydroxymethyl)morpholine

(S)-2-hydroxyMethyl-4-BOC-Morpholine

(S)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine

(S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.

135065-76-8

tert-butyl (S)-2-(hydroxymethyl)morpholine-4-carboxylate

ert-butyl(2S)-2-(hydroxymethyl)morpholine-4-carboxylate

(S)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH

N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol

135065-76-8

pharmacetical

API intermediates

Heterocycle-other series