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ChemicalBook > CAS DataBase List > (S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-(Hydroxymethyl)piperazine

Uses
Product Name
(S)-1-Boc-2-(Hydroxymethyl)piperazine
CAS No.
1030377-21-9
Chemical Name
(S)-1-Boc-2-(Hydroxymethyl)piperazine
Synonyms
(S)-1-Boc-2-(hyroxyMethyl)piperazine;(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE;(S)-N1-BOC-2-Hydroxymethyl-piperazine;(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected;(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate;(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate;tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate;(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber
CB9233339
Molecular Formula
C10H20N2O3
Formula Weight
216.28
MOL File
Mol file
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(S)-1-Boc-2-(Hydroxymethyl)piperazine Property

Boiling point:
324℃
Density 
1.085
Flash point:
150℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.97±0.10(Predicted)
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B600445
Product name
(S)-1-Boc-2-hydroxymethyl-piperazine
Packaging
100mg
Price
$85
Updated
2021/12/16
Activate Scientific
Product number
AS3135
Product name
(S)-1-Boc-2-(Hydroxymethyl)piperazine
Purity
95+% ee
Packaging
250mg
Price
$86
Updated
2021/12/16
ChemScene
Product number
CS-D0657
Product name
(S)-1-Boc-2-Hydroxymethyl-piperazine
Purity
>97.0%
Packaging
1g
Price
$94
Updated
2021/12/16
AK Scientific
Product number
X8638
Product name
(S)-1-Boc-(2-Hydroxymethyl)piperazine
Packaging
100mg
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
070014
Product name
(S)-1-Boc-2-(Hydroxymethyl)piperazine
Purity
96+%
Packaging
1g
Price
$165
Updated
2021/12/16
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(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemical Properties,Usage,Production

Uses

(S)-1-N-Boc-2-hydroxymethyl piperazine is a heterocyclic compound and can be used as an intermediate in pharmaceutical synthesis.

Uses

(S)-1-Boc-2-hydroxymethyl-piperazine is a heterocyclic building block used in synthetic chemistry.

Reactions

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.

Synthesis

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.

(S)-1-Boc-2-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-2-(Hydroxymethyl)piperazine Suppliers

Pharmavoyager
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China
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ForeChem (Nantong) Technology Co.,Ltd.
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Shanghai Sphchem Co., Ltd.
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View Lastest Price from (S)-1-Boc-2-(Hydroxymethyl)piperazine manufacturers

Career Henan Chemical Co
Product
(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1030377-21-9
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazineRelated Search:


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  • 1030377-21-9