(S)-1-Boc-2-(Hydroxymethyl)piperazine

ChemicalBook > CAS DataBase List > (S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-(Hydroxymethyl)piperazine

Uses

Product Name: (S)-1-Boc-2-(Hydroxymethyl)piperazine
CAS No.: 1030377-21-9
Chemical Name: (S)-1-Boc-2-(Hydroxymethyl)piperazine
Synonyms: (S)-1-Boc-2-(hyroxyMethyl)piperazine;(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE;(S)-N1-BOC-2-Hydroxymethyl-piperazine;(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected;(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate;(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate;tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate;(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber: CB9233339
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: Mol file

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(S)-1-Boc-2-(Hydroxymethyl)piperazine Property

Boiling point:: 324℃
Density: 1.085
Flash point:: 150℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 14.97±0.10(Predicted)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B600445
Product name: (S)-1-Boc-2-hydroxymethyl-piperazine
Packaging: 100mg
Price: $85
Updated: 2021/12/16

Activate Scientific

Product number: AS3135
Product name: (S)-1-Boc-2-(Hydroxymethyl)piperazine
Purity: 95+% ee
Packaging: 250mg
Price: $86
Updated: 2021/12/16

ChemScene

Product number: CS-D0657
Product name: (S)-1-Boc-2-Hydroxymethyl-piperazine
Purity: >97.0%
Packaging: 1g
Price: $94
Updated: 2021/12/16

AK Scientific

Product number: X8638
Product name: (S)-1-Boc-(2-Hydroxymethyl)piperazine
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 070014
Product name: (S)-1-Boc-2-(Hydroxymethyl)piperazine
Purity: 96+%
Packaging: 1g
Price: $165
Updated: 2021/12/16

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(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemical Properties,Usage,Production

Uses

(S)-1-N-Boc-2-hydroxymethyl piperazine is a heterocyclic compound and can be used as an intermediate in pharmaceutical synthesis.

Uses

(S)-1-Boc-2-hydroxymethyl-piperazine is a heterocyclic building block used in synthetic chemistry.

Reactions

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.

Synthesis

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.

(S)-1-Boc-2-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-1-Boc-2-(Hydroxymethyl)piperazine manufacturers

Career Henan Chemical Co

Product: (S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1030377-21-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazineRelated Search:

(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (R)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate (R)-1-N-Boc-2-(hydroxymethyl)piperazine (R)-4-benzyl-2-hydroxymethylpiperazine (S)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine (S)-4-benzyl-2-hydroxymethylpiperazine (S)-tert-butyl 2-(MethoxyMethyl)piperazine-1-carboxylate (S)-1-N-BOC-2-METHOXYMETHYLPIPERAZINE (S)-N-Boc-2-Hydroxymethylmorpholine (S)-N-Boc-2-aminomethylmorpholine tert-butyl (2R)-2-(MethoxyMethyl)piperazine-1-carboxylate tert-butyl (S)-2-(aminomethyl)-5-bromoindoline-1-carboxylate tert-butyl (S)-2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid

(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected

tert-Butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate, (2S)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine

tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate

tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate

(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE

1-PIPERAZINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER, (2S)-

(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate

(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate

(S)-1-Boc-2-(hyroxyMethyl)piperazine

1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate

(2S)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester

(S)-N1-BOC-2-Hydroxymethyl-piperazine

1030377-21-9