ChemicalBook > CAS DataBase List > (S)-N-Boc-2-Hydroxymethylmorpholine

(S)-N-Boc-2-Hydroxymethylmorpholine

Product Name
(S)-N-Boc-2-Hydroxymethylmorpholine
CAS No.
135065-76-8
Chemical Name
(S)-N-Boc-2-Hydroxymethylmorpholine
Synonyms
135065-76-8;(S)-N-Boc-2-HydroxyMethyl...;N-Boc-(S)-3-morpholine-methanol;(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(S)-2-hydroxyMethyl-4-BOC-Morpholine;(S)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;N-tert-Butyloxycarbonyl-(S)-2-morpholinemethanol;(2S)-2-(Hydroxymethyl)morpholine, N-BOC protected;(S)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine
CBNumber
CB3958331
Molecular Formula
C10H19NO4
Formula Weight
217.26
MOL File
135065-76-8.mol
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(S)-N-Boc-2-Hydroxymethylmorpholine Property

Melting point:
60-62 °C
Boiling point:
321 °C
Density 
1.118
Flash point:
148 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
14.36±0.10(Predicted)
form 
solid
color 
White
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
InChI
InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey
FJYBLMJHXRWDAQ-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCO[C@H](CO)C1
CAS DataBase Reference
135065-76-8
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
S960028
Product name
(S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-W003598
Product name
(S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Purity
≥97.0%
Packaging
10g
Price
$65
Updated
2021/12/16
AK Scientific
Product number
X9898
Product name
(S)-N-Boc-(2-Hydroxymethyl)morpholine
Packaging
1g
Price
$74
Updated
2021/12/16
ChemScene
Product number
CS-W003598
Product name
(S)-tert-Butyl2-(hydroxymethyl)morpholine-4-carboxylate
Purity
≥97.0%
Packaging
1g
Price
$16
Updated
2021/12/16
Activate Scientific
Product number
AS12059
Product name
(S)-N-Boc-morpholine-2-methanol
Purity
97+% ee
Packaging
1g
Price
$41
Updated
2021/12/16
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(S)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties,Usage,Production

Uses

(S)-N-Boc-2-hydroxymethylmorpholine is used as a pharmaceutical intermediate.

Synthesis

911223-10-4

135065-76-8

Under stirring conditions, (S)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate (5.27 g, 17.2 mmol) was dissolved in 200 mL of ethanol, followed by the addition of 0.527 g of palladium/activated carbon catalyst and two drops of 1N hydrochloric acid. The reaction system was replaced three times with hydrogen and then reacted overnight at 70 °C under hydrogen atmosphere, and the reaction progress was monitored by thin layer chromatography (TLC) until the feedstock was completely consumed. Upon completion of the reaction, the reaction was quenched with 100 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate (200 mL × 4). The organic phases were combined, washed sequentially with 100 mL of water and 100 mL of saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford (S)-N-Boc-2-hydroxymethylmorpholine (3.646 g, 97.7% yield) as colorless to light yellow liquid. Mass spectrum (ESI) m/z: 240.3 [M + 23]. 1H NMR (CDCl3, 400 MHz) δ 3.92-3.88 (m, 3H), 3.7-3.64 (m, 1H), 3.60-3.48 (m, 3H), 2.936 (m, 1H), 2.75 (m, 1H), 2.06 (m, 1H), 1.46 (s , 9H).

References

[1] Patent: EP2189451, 2010, A1. Location in patent: Page/Page column 14
[2] Patent: US2010/210640, 2010, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35
[4] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[5] Patent: WO2006/105262, 2006, A1. Location in patent: Page/Page column 74; 75

(S)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-Boc-2-Hydroxymethylmorpholine Suppliers

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View Lastest Price from (S)-N-Boc-2-Hydroxymethylmorpholine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8
Price
US $0.01/Kg/Drum
Min. Order
1g
Purity
99%+
Supply Ability
100T
Release date
2019-12-24
Career Henan Chemical Co
Product
(S)-N-Boc-2-Hydroxymethylmorpholine 135065-76-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

135065-76-8, (S)-N-Boc-2-HydroxymethylmorpholineRelated Search:

BUTYL OLEATE Butyl acetate Cyhalofop-butyl Moroxydine hydrochloride tert-Butyl peroxyacetate tert-Butyl acetate Buprofezin Tridemorph tert-Butanol Dimethomorph Moroxydine Tris(trimethylsilyl)phosphate (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (S)-N-Boc-2-aminomethylmorpholine (S)-1-Boc-2-(Hydroxymethyl)piperazine 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate

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  • (2S)-2-(Hydroxymethyl)morpholine, N-BOC protected
  • tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate, (2S)-4-(tert-Butoxycarbonyl)-2-(hydroxymethyl)morpholine
  • (S)-2-hydroxyMethyl-4-BOC-Morpholine
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  • (S)-N-Boc-2-hydroxymethylmorpholine,99%e.e.
  • 135065-76-8
  • tert-butyl (S)-2-(hydroxymethyl)morpholine-4-carboxylate
  • ert-butyl(2S)-2-(hydroxymethyl)morpholine-4-carboxylate
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  • pharmacetical
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