6-chloroquinolin-8-amine
- Product Name
- 6-chloroquinolin-8-amine
- CAS No.
- 5470-75-7
- Chemical Name
- 6-chloroquinolin-8-amine
- Synonyms
- NSC 2798;Nsc 27981;6-Chloro-8-quinolinamine;6-chloroquinolin-8-amine;8-Amino-6-chloroquinoline;6-Chloro-8-aminoquinoline;8-Quinolinamine, 6-chloro-;6-Chloroquinolin-8-amine 97%
- CBNumber
- CB11180454
- Molecular Formula
- C9H7ClN2
- Formula Weight
- 178.62
- MOL File
- 5470-75-7.mol
6-chloroquinolin-8-amine Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- Off-white to light yellow Solid
- EPA Substance Registry System
- 8-Quinolinamine, 6-chloro- (5470-75-7)
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C364300
- Product name
- 6-Chloro-8-aminoquinoline
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FC20169
- Product name
- 6-Chloro-8-aminoquinoline
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- OR500021
- Product name
- 6-Chloroquinolin-8-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 3H30-5-AQ
- Product name
- 6-Chloroquinolin-8-amine
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 7942AB
- Product name
- 6-Chloroquinolin-8-amine
- Packaging
- 5g
- Price
- $808
- Updated
- 2021/12/16
6-chloroquinolin-8-amine Chemical Properties,Usage,Production
Uses
6-Chloro-8-aminoquinoline is a di-substituted quinoline derivative used in the preparation fungitoxic analogs.
Uses
6-chloroquinolin-8-amine is a di-substituted quinoline derivative used in the preparation fungitoxic analogs.
Synthesis
68527-66-2
5470-75-7
Synthesis Method 2: Preparation of 6-chloro-8-aminoquinoline (precursor to Example Compound 4); To a stirred suspension of 6-chloro-8-nitroquinoline (Synthesis Method 1; 1.00 g, 4.79 mmol) in water (20 mL) was added acetic acid (0.82 mL, 14.3 mmol) and iron powder (1.61 g, 28.8 mmol) sequentially. The reaction mixture was heated to near reflux temperature, maintained for 1.5 h and then cooled to room temperature. Solid sodium hydroxide (0.65 g, 16.3 mmol) and ethyl acetate (30 mL) were added to the reaction system under continuous stirring. Diatomaceous earth (30 mL) was then added and the slurry was separated by filtration. The filter cake was washed with ethyl acetate. The combined filtrates were sequentially washed with aqueous sodium bicarbonate, dried over sodium sulfate and concentrated. The resulting brown viscous oil was purified by rapid chromatography on silica gel (eluent: hexane/ethyl acetate) to give 0.57 g of yellow solid product (67% yield). Product characterization data: 1H NMR (CDCl3) δ 8.71 (dd, J = 4.2, 1.5 Hz, 1H), 7.94 (dd, J = 8.3, 1.5 Hz, 1H), 7.36 (dd, J = 8.3, 4.2 Hz, 1H), 7.09 (d, J = 2.1 Hz, 1H), 6.84 (d, J = 2.1 Hz, 1H), 5.09 (br s, 2.1 Hz, 1H), 5.09 (br s, 2.1 Hz, 1H). 5.09 (br s, 2H) ppm.
References
[1] Monatshefte fuer Chemie, 1994, vol. 125, # 6/7, p. 723 - 730
[2] Monatshefte fuer Chemie, 1994, vol. 125, # 6/7, p. 723 - 730
[3] Patent: US2007/254894, 2007, A1. Location in patent: Page/Page column 21
[4] Patent: US2003/32645, 2003, A1
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1577
6-chloroquinolin-8-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-chloroquinolin-8-amine manufacturers
- Product
- 6-chloroquinolin-8-amine 5470-75-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18