ChemicalBook > CAS DataBase List > L-3,4-DIFLUOROPHENYLALANINE

L-3,4-DIFLUOROPHENYLALANINE

Product Name
L-3,4-DIFLUOROPHENYLALANINE
CAS No.
31105-90-5
Chemical Name
L-3,4-DIFLUOROPHENYLALANINE
Synonyms
L-3,4-DIFLUOROPHE;H-PHE(3,4-F 2)-OH;H-PHE(3,4-DIF)-OH;L-Phe(3,4-DiF)-OH;H-D-PHE(M,P-F2)-OH;H-L-Phe(3,4-F2)-OH;RARECHEM BK PT 0121;L-3,4-Difluoro-phe-OH;H-3,4-DIFLUORO-L-PHE-OH;4-Difuoro-L-phenylalanine
CBNumber
CB1122899
Molecular Formula
C9H9F2NO2
Formula Weight
201.17
MOL File
31105-90-5.mol
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L-3,4-DIFLUOROPHENYLALANINE Property

Boiling point:
311.9±42.0 °C(Predicted)
Density 
1.379±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Sealed in dry,Room Temperature
pka
2.16±0.20(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
31105-90-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D451195
Product name
3,4-Difluoro-L-phenylalanine
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
D451195
Product name
3,4-Difluoro-L-phenylalanine
Packaging
100mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
273873
Product name
L-3,4-Difluorophenylalanine
Packaging
500mg
Price
$333
Updated
2021/12/16
Apolloscientific
Product number
PC8363
Product name
3,4-Difluoro-L-phenylalanine
Packaging
5g
Price
$333
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD48010
Product name
L-3,4-Difluorophenylalanine
Packaging
2g
Price
$350
Updated
2021/12/16
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L-3,4-DIFLUOROPHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

Off-white solid powder

Synthesis

112897-97-9

31105-90-5

GENERAL METHODS: Suitable aldehydes 1j, 1n, or 1o (0.5 mmol), malonic acid (1.0 mmol), and piperidine (0.01 mmol) were dissolved in DMSO (500 mL), and the mixture was subsequently heated in a microwave reactor (60°C, 30 min). Upon completion of the reaction, the mixture was cooled to room temperature and ammonia solution (9.5 mL, 13% w/v, ~7 M, adjusted to pH 10.0 by slow addition of dry ice) was added, followed by addition of excess E. coli BL21(DE3) cells (400 mg wet cell paste) to catalyze the production of the target product, 3,4-difluoro-L-phenylalanine. The suspension was stirred at 37°C for several hours and the progress of the reaction was monitored by HPLC. To isolate the product, the reaction mixture was acidified to pH < 2.0 using aqueous sulfuric acid (20% w/v), followed by centrifugation (8000 rpm, 5 min) to remove the cells and the unconverted substrate precipitate. Dowex 50WX8 hydrogen-based resin (5.0 g) was loaded into a disposable plastic column and washed sequentially with deionized water (20 mL) and aqueous sulfuric acid solution (20 mL, 5% w/v). The supernatant after biotransformation was upsampled to the resin column at a flow rate of 1 mL/min. The resin bed was first rinsed with deionized water until the effluent was neutral, and then the product was eluted with aqueous ammonia solution (20 mL, 5% w/v). The product-containing fractions were combined and dried overnight in a centrifugal evaporator to give the corresponding L-phenylalanine derivatives L-3j, L-3n, or L-3o as white solids.4.7.1. (S)-2-Amino-3-(3,4-difluorophenyl)propionic acid (L-3j). Yield: 84 mg (84%), ee value 99% by HPLC.1H NMR (D2O/NaOH, 400 MHz), δ: 7.03-7.18 (m, 2H), 6.90-6.99 (m, 1H), 3.36-3.44 ( m, 1H), 2.81-2.90 (dd, J = 13.6, 6.0 Hz, 1H), 2.70-2.79 (dd, J = 13.6, 7.2 Hz, 1H).13C NMR (D2O/NaOH, 101 MHz), δ: 182.06, 150.94 ( dd, 1JCF = 243 Hz, 2JCF = 12 Hz), 150.09 (dd, 1JCF = 242 Hz, 2JCF = 13 Hz), 135.33 (dd, 3JCF = 5 Hz, 4JCF = 3 Hz), 125.51 (dd, 3JCF = 6 Hz, 4JCF = 3 Hz), 117.83 (d, 2JCF = 17 Hz), 116.97 (dd, 2JCF = 17 Hz), 57.33, 39.94. HRMS (ESI), m/z: calculated value 202.0680 [M?H]? , measured value 202.0689 [M?H]?

References

[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262

L-3,4-DIFLUOROPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-3,4-DIFLUOROPHENYLALANINE Suppliers

China 92 Germany 4 India 1 Japan 1 United Kingdom 3 United States 20 Global 121
chemcube
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sales@chemcube.eu
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Germany
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IRIS Biotech GmbH
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Germany
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4426
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Service Chemical Inc.
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sales@chemos-group.com
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Germany
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Rare Chemicals GmbH
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sales@rarechem.de
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Germany
ProdList
6297
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View Lastest Price from L-3,4-DIFLUOROPHENYLALANINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
L-3,4-DIFLUOROPHENYLALANINE 31105-90-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
L-3,4-DIFLUOROPHENYLALANINE 31105-90-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2019-12-31

31105-90-5, L-3,4-DIFLUOROPHENYLALANINERelated Search:

L-3,5-DIFLUOROPHE L-2-(5-Bromothienyl)alanine L-4-THIAZOLYLALANINE L-2-Bromophenylalanine 3-(2-Naphthyl)-L-alanine 3,3-Diphenyl-L-alanine 3,4-Dichlorophenylalanine 2,3,4-Trifluoro-L-phenylalanine L-3,4-DIFLUOROPHENYLALANINE BOC-L-3,4-DIFLUOROPHENYLALANINE,tert-butoxycarbonyl-l-3,4-difluorophenylalanine,Boc-3,4-difluorophenylalanine,N-TERT-BUTOXYCARBONYL-L-3,4-DIFLUOROPHENYLALANINE FMOC-D-3,4-Difluorophe N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-3,4-DIFLUOROPHENYLALANINE,FMOC-L-3,4-DIFLUOROPHENYLALANINE,Fluorenylmethoxycarbonyl-L-3,4-difluorophenylalanine 3,4-DIFLUOROPHENYLALANINE,Difluorophenylalanine4,DL-3,4-DIFLUOROPHENYLALANINE BOC-L-3,5-DIFLUOROPHENYLALANINE D-2,4-Difluorophenylalanine DL-2,5-DIFLUOROPHENYLALANINE,2,5-DIFLUOROPHENYLALANINE,Difluorophenylalanine21 FMOC-D-3,5-DIFLUOROPHENYLALANINE L-2,5-Difluorophenylalanine

  • RARECHEM BK PT 0121
  • (S)-2-AMINO-3-(3,4-DIFLUORO-PHENYL)-PROPIONIC ACID
  • H-PHE(3,4-DIF)-OH
  • H-PHE(3,4-F 2)-OH
  • L-3,4-DIFLUOROPHE
  • L-3,4-DIFLUOROPHENYLALANINE
  • H-D-PHE(M,P-F2)-OH
  • H-3,4-DIFLUORO-L-PHE-OH
  • 3,4-DIFLUORO-L-PHENYLALANINE
  • (2S)-2-amino-3-(3,4-difluorophenyl)propanoic acid
  • 3-(3,4-Difluorophenyl)-L-alanine
  • H-L-Phe(3,4-F2)-OH
  • 3,4-Difuoro-L-phenylalanine
  • 4-Difuoro-L-phenylalanine
  • L-3,4-Difluorophenylalanine H-3,4-difluoro-L-Phe-OH
  • L-Phenylalanine,3,4-difluoro-
  • L-3,4-Difluorophenylalanine98+%
  • L-Phe(3,4-DiF)-OH
  • (S)-2-AMino-3-(3,4-difluorophenyl)propanoic acid
  • L-3,4-Difluoro-phe-OH
  • (2S)-2-amino-3-(3,4-difluorophenyl)propanoicaci
  • L-3,4-DIFLUOROPHENYLALANINE USP/EP/BP
  • 31105-90-5
  • Phenylalanine analogs and other aromatic alpha amino acids
  • Amino Acids