3,3-Diphenyl-L-alanine
- Product Name
- 3,3-Diphenyl-L-alanine
- CAS No.
- 149597-92-2
- Chemical Name
- 3,3-Diphenyl-L-alanine
- Synonyms
- H-DPH-OH;H-Dip-OH;H-L-Dip-OH;CAS:149597-92-2;L-DiPhenylalanine;H-(3-PHENYL)PHE-OH;RARECHEM BK PT 0193;(S)-DIPHENYLALANINE;3-Diphenyl-L-alanine;L-3,3-DIPHENYLALANINE
- CBNumber
- CB2352404
- Molecular Formula
- C15H15NO2
- Formula Weight
- 241.29
- MOL File
- 149597-92-2.mol
3,3-Diphenyl-L-alanine Property
- Melting point:
- 234-240 °C
- Boiling point:
- 389.2±30.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 2.11±0.10(Predicted)
- color
- White
- InChI
- InChI=1/C15H15NO2/c16-14(15(17)18)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13-14H,16H2,(H,17,18)/t14-/s3
- InChIKey
- PECGVEGMRUZOML-AWEZNQCLSA-N
- SMILES
- C([C@H](N)C(=O)O)(C1=CC=CC=C1)C1=CC=CC=C1 |&1:1,r|
- CAS DataBase Reference
- 149597-92-2(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 86998
- Product name
- 3,3-Diphenyl-L-alanine
- Purity
- ≥98.0% (HPLC)
- Packaging
- 1g
- Price
- $282
- Updated
- 2023/06/20
- Product number
- D462640
- Product name
- L-3,3-Diphenylalanine
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 453139
- Product name
- L-3,3-Diphenylalanine
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- FD48021
- Product name
- 3,3-Diphenyl-L-alanine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 04129
- Product name
- 3,3-Diphenyl-L-alanine
- Purity
- ≥ 99%
- Packaging
- 1G
- Price
- $65
- Updated
- 2021/12/16
3,3-Diphenyl-L-alanine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
3,3-Diphenyl-L-alanine is used as organic chemical synthesis intermediate.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
1004755-24-1
149597-92-2
Step 2: 1,1-dimethylethyl-(2R)-(2,6-dichlorophenyl)-(4S)-(diphenylmethyl)-5-oxo-3-((1'R)-phenylethyl)tetrahydro-1H-1-imidazolecarboxylate (188 mg, 0.31 mmol) was dissolved in a solvent mixture of 7.5 mL of tetrahydrofuran and 1 mL of 1 M hydrochloric acid, and the atmosphere of the reaction vessel was replaced with nitrogen. . To the mixture was added 90 mg of 20% palladium-carbon hydroxide catalyst; the atmosphere was again replaced with nitrogen and then hydrogen. After 100 hours of reaction at room temperature and 2.2 MPa hydrogen pressure, the catalyst was separated by filtration. The resulting product was washed once with 5 mL of tetrahydrofuran and 3 mL of distilled water, respectively, and the solvent was removed under reduced pressure. To the mixture was added 7.5 mL of 6M hydrochloric acid; the mixture was heated and refluxed at an external temperature of 120-130°C for 2.5 hours. Thereafter, the reaction mixture was cooled to an external temperature of 0°C. After adjusting the pH to 6 to 7 by adding 30% aqueous sodium hydroxide solution thereto, the solvent was removed under reduced pressure. The amount of (S)-2-amino-3,3-diphenylpropionic acid contained in the residue was determined under the following analytical conditions. As a result, the yield was 76% and the ee value was 95.7%.
References
[1] Patent: EP2050738, 2009, A1. Location in patent: Page/Page column 39-40
3,3-Diphenyl-L-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,3-Diphenyl-L-alanine manufacturers
- Product
- L-3,3-Diphenylalanine 149597-92-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 3,3-Diphenyl-L-alanine 149597-92-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24