ChemicalBook > CAS DataBase List > METHYL2-CHLORO-5-FLUORONICOTINATE

METHYL2-CHLORO-5-FLUORONICOTINATE

Product Name: METHYL2-CHLORO-5-FLUORONICOTINATE
CAS No.: 847729-27-5
Chemical Name: METHYL2-CHLORO-5-FLUORONICOTINATE
Synonyms: 136438;METHYL2-CHLORO-5-FLUORONICOTINATE;2-Chloro-5-fluoro-nicotinic acid Methyl ester;methyl 2-chloro-5-fluoropyridine-3-carboxylate;2-chloro-5-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, methyl ester
CBNumber: CB11229337
Molecular Formula: C7H5ClFNO2
Formula Weight: 189.57
MOL File: 847729-27-5.mol

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METHYL2-CHLORO-5-FLUORONICOTINATE Property

Boiling point:: 235.4±40.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: -3.73±0.10(Predicted)
InChIKey: VYUNQTNDEVFXPO-UHFFFAOYSA-N
CAS DataBase Reference: 847729-27-5

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000416
Product name: Methyl 2-chloro-5-fluoronicotinate
Purity: Aldrich
Packaging: 1g
Price: $550
Updated: 2025/07/31

TRC

Product number: M295590
Product name: Methyl 2-chloro-5-fluoronicotinate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 026194
Product name: Methyl 2-chloro-5-fluoronicotinate
Packaging: 1g
Price: $103
Updated: 2021/12/16

Apolloscientific

Product number: PC200135
Product name: Methyl 2-chloro-5-fluoronicotinate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: PC200135
Product name: Methyl 2-chloro-5-fluoronicotinate
Packaging: 1g
Price: $145
Updated: 2021/12/16

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METHYL2-CHLORO-5-FLUORONICOTINATE Chemical Properties,Usage,Production

Uses

Methyl 2-chloro-5-fluoronicotinate

Synthesis

38186-88-8

18107-18-1

847729-27-5

Example 58 Synthesis of 4-((5-fluoro-2-(4-fluorophenyl)pyridin-3-yl]methyl}amino)methylbenzoic acid Procedure 1. Preparation of methyl 5-fluoro-2-(4-fluorophenyl)nicotinate: 2-chloro-5-fluoronicotinic acid (1.00 g, 5.70 mmol) was dissolved in a mixture of solvents of methanol (4 mL) and dichloromethane (14 mL) at 0 °C, and slowly added to a 2M hexane solution of trimethylsilylated diazomethane (5.70 mL, 11.4 mmol). The reaction mixture was stirred at 0 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with acetic acid and the solvent was removed by concentration under reduced pressure. The residue was purified by fast column chromatography on silica gel using hexane/ethyl acetate (10:1, v/v) as eluent to afford 0.78 g (72% yield) of methyl 2-chloro-5-fluoronicotinate as a colorless oil. The product was characterized by 1H-NMR (CDCl3): δ 8.41 (1H, d, J=3.1 Hz), 7.93 (1H, dd, J=7.6,3.1 Hz), 3.98 (3H, s).

References

[1] Patent: WO2005/21508, 2005, A1. Location in patent: Page/Page column 97
[2] Patent: WO2005/102389, 2005, A2. Location in patent: Page/Page column 142-143

METHYL2-CHLORO-5-FLUORONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL2-CHLORO-5-FLUORONICOTINATE manufacturers

Career Henan Chemical Co

Product: METHYL2-CHLORO-5-FLUORONICOTINATE 847729-27-5
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 5kg, 50kg
Release date: 2020-01-09

847729-27-5, METHYL2-CHLORO-5-FLUORONICOTINATERelated Search:

Permethrin 2-Chloro-6-trifluoromethoxy-isonicotinic acid methyl ester ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate METHYL 2,6-DICHLORO-5-FLUORONICOTINATE Ethyl 2-chloro-5-fluoronicotinate 3-METHOXYPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE PHENYL 2,6-DICHLORO-5-FLUORONICOTINATE 2,6-DIMETHYLPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE METHYL2-CHLORO-5-FLUORONICOTINATE

METHYL2-CHLORO-5-FLUORONICOTINATE

2-Chloro-5-fluoro-nicotinic acid Methyl ester

methyl 2-chloro-5-fluoropyridine-3-carboxylate

2-chloro-5-fluoro-3-pyridinecarboxylic acid methyl ester

136438

3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, methyl ester

847729-27-5