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CP-4126 (LVT derivative of Gemcitabine)

Product Name
CP-4126 (LVT derivative of Gemcitabine)
CAS No.
210829-30-4
Chemical Name
CP-4126 (LVT derivative of Gemcitabine)
Synonyms
CS-1569;CP 4126;GeMcitabine elaidate;GeMcitabine 5'-elaidate;Gemcitabine elaidate(CP-4126;CO-101:CP-4126:Gemcitabineelaidate;Gemcitabine elaidate，CO-101，CP-4126;CP-4126 (LVT derivative of Gemcitabine);CO-101; CP-4126; GEMCITABINE 5'-ELAIDATE;Gemcitabine elaidate (Anti oleic acid gemcitabine)
CBNumber
CB11231859
Molecular Formula
C27H43F2N3O5
Formula Weight
527.64
MOL File
210829-30-4.mol
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CP-4126 (LVT derivative of Gemcitabine) Property

Boiling point:
631.4±65.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Ethanol:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.63(Max Conc. mM)
DMSO:28.0(Max Conc. mg/mL);53.07(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);56.86(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);56.86(Max Conc. mM)
form 
A crystalline solid
pka
11.48±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28303
Product name
Gemcitabine Elaidate
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28303
Product name
Gemcitabine Elaidate
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
28303
Product name
Gemcitabine Elaidate
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28303
Product name
Gemcitabine Elaidate
Packaging
10mg
Price
$214
Updated
2024/03/01
ChemScene
Product number
CS-3744
Product name
Gemcitabine(elaidate)
Purity
99.24%
Packaging
5mg
Price
$126
Updated
2021/12/16
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CP-4126 (LVT derivative of Gemcitabine) Chemical Properties,Usage,Production

Uses

Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity[1][2].

Definition

ChEBI: Gemcitabine elaidate is a pyrimidine 2'-deoxyribonucleoside.

in vivo

Gemcitabine elaidate (25-120 mg/kg; i.p. every 3 days for 5 doses) inhibits the solid tumor xenografts growth of non-small cell lung cancer (EKVX), non-classifiable sarcoma (MHMX), fibrous histiocytoma (TAX II-1), malignant melanoma (THX), prostate cancer (CRL-1435), pancreatic cancer (PANC-1)[1].
Gemcitabine elaidate (10-20 mg/kg; p.o. every 3 days for 5 doses) shows acceptable toxicity and significant antitumor activity in the colon cancer xenograft Co6044 bearing mice[1].
Gemcitabine elaidate (p.o. once daily for 5 doses) shows a favorable toxicity and antitumor activity, while the dose of 15 mg/kg is highly toxic in the human colon cancer xenograft Co6044[1].

Animal Model:Female BALB/c nude (nu/nu) mice (5-8 weeks; 20-27 g) were bearing tumor of EKVX, H-146, MHMX, TAX II-1, OHS, THX, MA-11, CRL-1435, PANC-1 and MiaPaCa-2, respectively[1]
Dosage:25-120 mg/kg
Administration:I.p. every 3 days for 5 doses
Result:Inhibited the growth of EKVX, MHMX, TAX II-1, THX, CRL-1435 and PANC-1, with T/C values of 7%, 1%, 30%, 7%, 9%, and 12%, respectively.

References

[1] Bergman AM, et, al. Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2011 Jun;29(3):456-66. DOI:10.1007/s10637-009-9377-7
[2] Adema AD, et, al. Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36(1):285-94. PMID:19956857

CP-4126 (LVT derivative of Gemcitabine) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-4126 (LVT derivative of Gemcitabine) Suppliers

China 72 United Kingdom 2 United States 12 Global 86
Carbosynth Limited
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6581
Advantage
61
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
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View Lastest Price from CP-4126 (LVT derivative of Gemcitabine) manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
CP-4126 (LVT derivative of Gemcitabine) 210829-30-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gemcitabine elaidate 210829-30-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Gemcitabine elaidate 210829-30-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

210829-30-4, CP-4126 (LVT derivative of Gemcitabine)Related Search:

Methyl Oleate LinoelaidicAcid(9tr,12tr)) ElaidicAcid(9tr) ELAIDIC ACID ETHYL ESTER glycerine monostearate Gemcitabine

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