1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

Product Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
CAS No.: 5627-05-4
Chemical Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
Synonyms: dihydrouridine;6-Dihydrouridine;Uridine, 5,6-dihydro-;Uridine Impurity 28（5,6-Dihydrouridine）;5,6-Dihydrouridine RNA-modified nucleoside D;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
CBNumber: CB11235574
Molecular Formula: C9H14N2O6
Formula Weight: 246.22
MOL File: 5627-05-4.mol

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1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Property

Density: 1.614±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form: A crystalline solid
pka: 12.40±0.20(Predicted)
color: White to off-white
PH: ～11
λmax: 208 (in H2O)
Stability:: Hygroscopic

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D449668
Product name: 5,6-Dihydrouridine
Packaging: 100mg
Price: $800
Updated: 2021/12/16

TRC

Product number: D449668
Product name: 5,6-Dihydrouridine
Packaging: 250mg
Price: $1755
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H12-1-03
Product name: 5,6-Dihydrouridine
Purity: 95%
Packaging: 250mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-0059431
Product name: 5,6-Dihydrouridine
Purity: 99.87%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001384
Product name: 5,6-DIHYDRO-URIDINE
Purity: 95.00%
Packaging: 5MG
Price: $501.22
Updated: 2021/12/16

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1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties,Usage,Production

Uses

5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.

Definition

ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring.

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Suppliers

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5627-05-4, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-oneRelated Search:

dihydrouridine

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

Uridine, 5,6-dihydro-

Uridine Impurity 28（5,6-Dihydrouridine）

6-Dihydrouridine

5,6-Dihydrouridine RNA-modified nucleoside D

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione

5627-05-4