1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
- Product Name
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
- CAS No.
- 5627-05-4
- Chemical Name
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
- Synonyms
- dihydrouridine;6-Dihydrouridine;Uridine, 5,6-dihydro-;Uridine Impurity 28（5,6-Dihydrouridine）;5,6-Dihydrouridine RNA-modified nucleoside D;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
- CBNumber
- CB11235574
- Molecular Formula
- C9H14N2O6
- Formula Weight
- 246.22
- MOL File
- 5627-05-4.mol
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Property
- Density
- 1.614±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- A crystalline solid
- pka
- 12.40±0.20(Predicted)
- Stability:
- Hygroscopic
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D449668
- Product name
- 5,6-Dihydrouridine
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- D449668
- Product name
- 5,6-Dihydrouridine
- Packaging
- 250mg
- Price
- $1755
- Updated
- 2021/12/16
- Product number
- 4H12-1-03
- Product name
- 5,6-Dihydrouridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-0059431
- Product name
- 5,6-Dihydrouridine
- Purity
- 99.87%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- NUC0001384
- Product name
- 5,6-DIHYDRO-URIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.22
- Updated
- 2021/12/16
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties,Usage,Production
Uses
5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
Definition
ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring.