ChemicalBook > CAS DataBase List > 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide

4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide

Product Name
4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide
CAS No.
154540-49-5
Chemical Name
4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide
Synonyms
fluoroclebopride;Fluoroclebopride, 10 mM in DMSO;Abmole M4962-10mg fluoroclebopride 154540-49-5;Abmole M4962-50mg fluoroclebopride 154540-49-5;Inhibitor,inhibit,Fluoroclebopride,Dopamine Receptor;4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide;Benzamide,4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-
CBNumber
CB11242925
Molecular Formula
C20H23ClFN3O2
Formula Weight
391.87
MOL File
154540-49-5.mol
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4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Property

Boiling point:
518.2±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
13.62±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23447
Product name
Fluoroclebopride
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
23447
Product name
Fluoroclebopride
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
23447
Product name
Fluoroclebopride
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
AK Scientific
Product number
9031CA
Product name
Fluoroclebopride
Packaging
5mg
Price
$276
Updated
2021/12/16
DC Chemicals
Product number
DC9669
Product name
Fluoroclebopride
Purity
>98%
Packaging
100mg
Price
$500
Updated
2021/12/16
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4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Chemical Properties,Usage,Production

Description

Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications. It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays). It is selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively). A fluorine-18 moiety has been used to label this compound for use as a probe for studying D2/D3 receptor availability via PET in various monkey models.

Uses

Fluoroclebopride binds reversibly to dopamine receptors. 18F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models[1][2].

References

[1] Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug;162(8):1473-82. DOI:10.1176/appi.ajp.162.8.1473
[2] Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29:10.1007/s00213-013-3274-7. DOI:10.1007/s00213-013-3274-7. doi: 10.1007/s00213-013-3274-7

4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide Suppliers

China 44 Switzerland 1 United States 6 Global 51
Shanghai Boyle Chemical Co., Ltd.
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+86-21-58447131
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154540-49-5, 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamideRelated Search:


  • 4-Amino-5-chloro-N-(1-((4-fluorophenyl)methyl)-4-piperidinyl)-2-methox ybenzamide
  • fluoroclebopride
  • Benzamide,4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-
  • Inhibitor,inhibit,Fluoroclebopride,Dopamine Receptor
  • Fluoroclebopride, 10 mM in DMSO
  • Abmole M4962-50mg fluoroclebopride 154540-49-5
  • Abmole M4962-10mg fluoroclebopride 154540-49-5
  • 154540-49-5
  • C20H23ClFN3O2