Quinupristin-dalfopristin
- Product Name
- Quinupristin-dalfopristin
- CAS No.
- 126602-89-9
- Chemical Name
- Quinupristin-dalfopristin
- Synonyms
- SYNERCID;Quinupristin-dalfopristin;Mixture with quinupristin;Quinupristin-Dalfopristin complex;Quinupristin dalfopristin mesylate;Quinipristine+ Dalfopristin Mesylate;Mepanipyrim Impurity 2-d5 (Cyprodinil-d5);Quinupristin-Dalfopristin Mesylate coMplex;Synercid coMplex, Dalfopristin-Quinupristin coMplex;Quinupristin-dalfopristin Mesylate complex DISCONTINUED
- CBNumber
- CB11252296
- Molecular Formula
- C87H117N13O19S2
- Formula Weight
- 1713.09
- MOL File
- 126602-89-9.mol
Quinupristin-dalfopristin Property
- InChI
- InChI=1/C53H67N9O10S.C34H50N4O9S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46;1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65);9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b;10-9-,12-11+,23-18+/t31-,35+,37-,38+,39+,40+,43-,44+,45+;24-,25-,28-,31-,32+/s3
- InChIKey
- PPKJUHVNTMYXOD-JAPDWZECNA-N
- SMILES
- S([C@@H]1CCN2C(C3=COC(CC(C[C@@H](C=C(C)C=CCNC(=O)C=C[C@@H](C)[C@H](C(C)C)OC(=O)[C@@]12[H])O)=O)=N3)=O)(=O)(=O)CCN(CC)CC.O=C1[C@@]([H])(N(C([C@]2([H])CCCN2C([C@H](NC(=O)[C@@H](NC(C2N=CC=CC=2O)=O)[C@@H](C)OC(=O)[C@H](C2C=CC=CC=2)NC(=O)[C@]2([H])CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN12)CC)=O)=O)C)CC1C=CC(N(C)C)=CC=1 |c:14,17,t:23,&1:1,13,25,27,34,51,55,62,66,77,82,92,97,100,r|
Quinupristin-dalfopristin Chemical Properties,Usage,Production
Description
Dalfopristin and Quinupristin are two well-defined semi-synthetic antibacterials belonging to the class of streptogramins. Together, they form Synercid, an injectable formulation in a ratio 70 : 30 that was launched in the UK followed by the US. The two distinct antibiotic agents, pristinamycins, are bacteriostatic in their own right but, when they are in association, act synergistically at the ribosomal level to inhibit protein synthesis. Synercid is the first antibiotic in its class to reach the market. It appears to be a sound treatment alternative for patients with severe or life-threatening infections, such as the most problematic forms of gram-positive nosocomial sepsis including vancomycin-resistant Enterococcus faecium (VREF) or methicillinresistant Staphylococcus aureus (MRSA).
Originator
Rhone-Poulenc-Rorer (France)
Uses
Quinupristin-dalfopristin mesylate complex is a 70:30 complex that functions as an antibiotic.
Uses
Quinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as SynercidTM. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.
brand name
Synercid
Quinupristin-dalfopristin Preparation Products And Raw materials
Raw materials
Preparation Products
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