Quinupristin
- Product Name
- Quinupristin
- CAS No.
- 120138-50-3
- Chemical Name
- Quinupristin
- Synonyms
- RP 68888;RP 57669;Antibiotic RP 57669;Quinupristin Mesylate;Quinupristin(RP-57669);Quinupristin Discontinued;Quinupristin/dalfopristin,Quinupristin,antibiotic,Quinupristin-dalfopristin,streptogramin,Inhibitor,Bacterial,inhibit;4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1;Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-
- CBNumber
- CB81073487
- Molecular Formula
- C53H67N9O10S
- Formula Weight
- 1022.23
- MOL File
- 120138-50-3.mol
Quinupristin Property
- Melting point:
- ~200°
- form
- Solid
- color
- White to off-white
Safety
- Hazardous Substances Data
- 120138-50-3(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 19764
- Product name
- Quinupristin (mesylate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $255
- Updated
- 2024/03/01
- Product number
- 19764
- Product name
- Quinupristin (mesylate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $952
- Updated
- 2024/03/01
- Product number
- API0004691
- Product name
- QUINUPRISTIN
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1963.5
- Updated
- 2021/12/16
- Product number
- C5450
- Product name
- Quinupristin(mesylate)
- Packaging
- 1mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- API0004691
- Product name
- QUINUPRISTIN
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $750.75
- Updated
- 2021/12/16
Quinupristin Chemical Properties,Usage,Production
Description
Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.
Uses
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Uses
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Uses
Semisynthetic depsipeptide type I streptogramin. An antibacterial agent.
Quinupristin Preparation Products And Raw materials
Raw materials
Preparation Products
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