Tussilagone

Product Name: Tussilagone
CAS No.: 104012-37-5
Chemical Name: Tussilagone
Synonyms: L 652469;Tussilagone;Tussilagone-RM;Tussilagone, 98%, from Farfarae Flos;(1S,3aR,5R,7S,7aS)-1-((R)-1-Acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate;(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate;2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-
CBNumber: CB11253147
Molecular Formula: C23H34O5
Formula Weight: 390.51
MOL File: 104012-37-5.mol

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Tussilagone Property

Boiling point:: 471.3±35.0 °C(Predicted)
Density: 1.07±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
form: Solid
color: White to off-white
InChIKey: CFUPNMDNSQIWBB-UUVDBSHOSA-N
SMILES: C(O[C@@H]1C[C@@H](C(C)C)[C@@]2([H])[C@]([H])(C1=C)CC(=O)[C@@H]2[C@H](OC(C)=O)C)(=O)/C=C(\C)/CC

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Safety

Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 301089
Product name: Tussilagone
Packaging: 10mg
Price: $453
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259543
Product name: Tussilagone
Purity: 98%
Packaging: 20mg
Price: $418.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HBL0000398
Product name: TUSSILAGONE
Purity: 95.00%
Packaging: 5MG
Price: $503.69
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb105062
Product name: Tussilagone
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 74121
Product name: Tussilagone
Purity: 98%
Packaging: 20mg
Price: $600
Updated: 2021/12/16

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Tussilagone Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in ether, chloroform, ethyl acetate, methanol, insoluble in water, derived from the flower bud of Asteraceae Tussilago farfara, Senecio kleinia Less root.

Uses

Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2].

Biological Activity

Tussilagone, the main active ingredient of Tussilago farfara, has anti-inflammatory properties. It ameliorates the inflammatory response of dextran sulfate sodium-induced colitis in mice.

in vivo

Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.

References

[1] Cheon HJ, et al. Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Chem Biol Interact. 2018 Oct 1;294:74-80. DOI:10.1016/j.cbi.2018.08.022
[2] Kim YK, et al. Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced SepticMice. Int J Mol Sci. 2017 Dec 18;18(12). pii: E2744. DOI:10.3390/ijms18122744

Tussilagone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tussilagone Suppliers

China 148 United States 8 USA 1 Global 157

Chengdu Peter-like Biotechnology Co., Ltd.

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ShangHai YuanYe Biotechnology Co., Ltd.

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Chengdu Biopurify Phytochemicals Ltd.

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Shanghai Tauto Biotech Co., Ltd.

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Cheng Du Pufeide Biotechnology Co., Ltd.

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Shanghai BeiZhuo Biotech Co., Ltd.

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Shanghai Aspire Biological Technology Co., Ltd.

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Fax: 021-61486878
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Country: China
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View Lastest Price from Tussilagone manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Tussilagone 104012-37-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-07

Career Henan Chemical Co

Product: Tussilagone 104012-37-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

104012-37-5, TussilagoneRelated Search:

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Tussilagone

L 652469

Tussilagone, 98%, from Farfarae Flos

2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-

(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate

(1S,3aR,5R,7S,7aS)-1-((R)-1-Acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate

Tussilagone-RM

104012-37-5