Tiplaxtinin

Product Name: Tiplaxtinin
CAS No.: 393105-53-8
Chemical Name: Tiplaxtinin
Synonyms: PAI-039;CS-1464;tiplasinin;Tiplaxtinin;PAI 039 Tiplaxtinin;TIPLAXTININ(PAI-039);Tiplaxtinin >=98% (HPLC);Tiplaxtinin(PAI-039), >98%;TIPLAXTININ;PAI039;PAI 039;2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
CBNumber: CB11261085
Molecular Formula: C24H16F3NO4
Formula Weight: 439.38
MOL File: 393105-53-8.mol

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Tiplaxtinin Property

Melting point:: 164-167℃
Density: 1.34
storage temp.: -20°C
solubility: DMSO (Sparingly), Methanol (Slightly)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0295
Product name: Tiplaxtinin
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $115
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0295
Product name: Tiplaxtinin
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 9000450
Product name: Tiplaxtinin
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 9000450
Product name: Tiplaxtinin
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 9000450
Product name: Tiplaxtinin
Purity: ≥98%
Packaging: 10mg
Price: $142
Updated: 2024/03/01

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Tiplaxtinin Chemical Properties,Usage,Production

Description

Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC₅₀ = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.

Uses

Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.

Definition

ChEBI: Tiplasinin is a member of indole-3-acetic acids. It is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.

Biochem/physiol Actions

Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.

storage

Store at +4°C

Tiplaxtinin Preparation Products And Raw materials

Raw materials

Preparation Products

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Tiplaxtinin Suppliers

China 90 India 1 United Kingdom 1 United States 17 Global 109

Target molecule Corp.

Tel: 857-239-0968
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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

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NE Scientific

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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Combi-Blocks Inc.

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Axon Medchem LLC

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View Lastest Price from Tiplaxtinin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tiplaxtinin 393105-53-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tiplaxtinin 393105-53-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d 393105-53-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

393105-53-8, TiplaxtininRelated Search:

(S)-(+)-Benzyl glycidyl ether Poly(methyl methacrylate) Benzyl alcohol TRIMETHYLPHOSPHINE OXIDE 4'-Hydroxyacetophenone

2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid

TIPLAXTININ(PAI-039)

1H-Indole-3-aceticacid, a-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-

2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d

tiplasinin

Tiplaxtinin

PAI-039

alpha-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

PAI 039 Tiplaxtinin

Tiplaxtinin(PAI-039), >98%

α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

CS-1464

TIPLAXTININ;PAI039;PAI 039

1H-Indole-3-acetic acid, α-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-

Tiplaxtinin >=98% (HPLC)

393105-53-8

C24H16F3NO4

Inhibitors