Methyl 6-amino-3-bromopicolinate

Product Name: Methyl 6-amino-3-bromopicolinate
CAS No.: 178876-83-0
Chemical Name: Methyl 6-amino-3-bromopicolinate
Synonyms: Methyl 6-amino-3-bromopicolinate;Methyl 6-Amino 3-Bromo 2-Picolinate;methyl 6-amino-3-bromo-2-pyridinecarboxylate;Methyl 6-amino-3-bromopyridine-2-carboxylate;Methyl 6-amino-3-bromopicolinate ISO 9001：2015 REACH;6-Amino-3-bromo-pyridine-2-carboxylic acid methyl ester;methyl 3-bromo-6-imino-1,6-dihydropyridine-2-carboxylate;2-Pyridinecarboxylic acid, 6-amino-3-bromo-, methyl ester;6-amino-3-bromo-2-Pyridinecarboxylic acid methyl ester (9CI ACI);2-Pyridinecarboxylic acid, 6-amino-3-bromo-, methyl ester (9CI, ACI)
CBNumber: CB11263458
Molecular Formula: C7H7BrN2O2
Formula Weight: 231.05
MOL File: 178876-83-0.mol

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Methyl 6-amino-3-bromopicolinate Property

Boiling point:: 333.4±37.0 °C(Predicted)
Density: 1.662±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.12±0.10(Predicted)
form: solid
color: Off white
InChI: InChI=1S/C7H7BrN2O2/c1-12-7(11)6-4(8)2-3-5(9)10-6/h2-3H,1H3,(H2,9,10)
InChIKey: YJUKTIBOUBUOJH-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(N)=CC=C1Br

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Safety

Hazard Codes: Xi
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M289408
Product name: Methyl6-Amino-3-bromopyridine-2-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M289408
Product name: Methyl6-Amino-3-bromopyridine-2-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: M289408
Product name: Methyl6-Amino-3-bromopyridine-2-carboxylate
Packaging: 500mg
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-9-00
Product name: Methyl 6-amino-3-bromopyridine-2-carboxylate
Packaging: 1g
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: W3896
Product name: Methyl6-amino-3-bromopyridine-2-carboxylate
Packaging: 5g
Price: $355
Updated: 2021/12/16

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Methyl 6-amino-3-bromopicolinate Chemical Properties,Usage,Production

Synthesis

36052-26-3

178876-83-0

178876-82-9

General procedure for the synthesis of methyl 6-amino-3-bromopyridine-2-carboxylate and methyl 5-bromo-6-aminopyridine-2-carboxylate from methyl 6-aminopyridine-2-carboxylate: (d) Synthesis of methyl 6-amino-5-bromopyridine-2-carboxylate: to a solution of methyl 6-aminopyridine-2-carboxylate (10 g, 66.0 mmol) in chloroform (450 mL) was slowly added a solution of bromine (3.4 mL, 66.0 mmol) in chloroform (100 mL) at room temperature, and the reaction mixture was stirred for 40 hours. After completion of the reaction, the reaction mixture was diluted with chloroform and washed sequentially with saturated sodium thiosulfate solution and water. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using ethyl acetate/hexane as eluent to afford methyl 6-amino-3-bromopyridine-2-carboxylate as a yellow solid (3.3 g, 22% yield). Mass spectrum (ESI) m/e: 231.0 [M+H]+. 1H NMR (CDCl3, 400MHz): δ (ppm) = 7.76 (d, J = 7.88Hz, 1H), 7.34 (d, J = 7.92Hz, 1H), 5.23 (s, 2H), 3.94 (s, 3H). d) Isolation of methyl 6-amino-3-bromopyridine-2-carboxylate: In step d) above, the isomer methyl 6-amino-3-bromopyridine-2-carboxylate (3.0 g, 19% yield) was also isolated as a by-product. Mass spectrum (ESI) m/e: 231.2 [M+H]+. 1H NMR (CDCl3, 400MHz): δ (ppm) = 7.60 (d, J = 8.72Hz, 1H), 6.47 (d, J = 7.88Hz, 1H), 4.71 (s, 2H), 3.94 (s, 3H).

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4623 - 4633
[2] Organic Process Research and Development, 2010, vol. 14, # 1, p. 263 - 271
[3] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5035 - 5037
[4] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 129; 130

Methyl 6-amino-3-bromopicolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 6-amino-3-bromopicolinate Suppliers

China 115 Germany 1 India 5 United Kingdom 1 United States 15 Global 137

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View Lastest Price from Methyl 6-amino-3-bromopicolinate manufacturers

Dideu Industries Group Limited

Product: Methyl 6-amino-3-bromopicolinate 178876-83-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 6-amino-3-bromopicolinate 178876-83-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: Methyl 6-amino-3-bromopicolinate 178876-83-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-11

178876-83-0, Methyl 6-amino-3-bromopicolinateRelated Search:

6-AMINOPICOLINIC ACID METHYL ESTER (3-bromopyridin-2-yl)methanol 4-Chlorophenethylamine 3-BROMOPYRIDINE-2-CARBOXYLIC ACID Methyl 6-amino-3-bromopicolinate

Methyl 6-amino-3-bromopicolinate

Methyl 6-amino-3-bromopyridine-2-carboxylate

methyl 6-amino-3-bromo-2-pyridinecarboxylate

6-Amino-3-bromo-pyridine-2-carboxylic acid methyl ester

2-Pyridinecarboxylic acid, 6-amino-3-bromo-, methyl ester

Methyl 6-amino-3-bromopicolinate ISO 9001：2015 REACH

2-Pyridinecarboxylic acid, 6-amino-3-bromo-, methyl ester (9CI, ACI)

6-amino-3-bromo-2-Pyridinecarboxylic acid methyl ester (9CI ACI)

methyl 3-bromo-6-imino-1,6-dihydropyridine-2-carboxylate

Methyl 6-Amino 3-Bromo 2-Picolinate

178876-83-0

blocks

Bromides

Carboxes

Pyridines