1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI)
Uses- Product Name
- 1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI)
- CAS No.
- 632365-54-9
- Chemical Name
- 1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI)
- Synonyms
- MFCD16039361;1H-Pyrazole-3-carboxylicacid,5-am;Methyl 5-AMinopyrazole-3-carboxylate;methyl 5-amino-2H-pyrazole-3-carboxylate;Methyl 3-aMino-1H-pyrazole-5-carboxylate;Ethyl 5-amino-1h-pyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylicacid,5-amino-,methyles;5-Aminopyrazole-3-carboxylic acid methyl ester;1H-Pyrazole-3-carboxylicacid,5-amino-,methylester;5-amino-2H-pyrazole-3-carboxylic acid methyl ester
- CBNumber
- CB11282402
- Molecular Formula
- C5H7N3O2
- Formula Weight
- 141.13
- MOL File
- 632365-54-9.mol
1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI) Property
- Melting point:
- 135～136℃
- Boiling point:
- 397.8±22.0 °C(Predicted)
- Density
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 12.32±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5H7N3O2/c1-10-5(9)3-2-4(6)8-7-3/h2H,1H3,(H3,6,7,8)
- InChIKey
- WUKSVVOCYHTIMV-UHFFFAOYSA-N
- SMILES
- N1C(N)=CC(C(OC)=O)=N1
- CAS DataBase Reference
- 632365-54-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M288545
- Product name
- methyl5-amino-1H-pyrazole-3-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- CS-W006219
- Product name
- Methyl3-amino-1H-pyrazole-5-carboxylate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $294
- Updated
- 2021/12/16
- Product number
- 4H58-1-UU
- Product name
- Methyl 3-amino-1H-pyrazole-5-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- W7526
- Product name
- Methyl5-amino-1H-pyrazole-3-carboxylate
- Packaging
- 5g
- Price
- $489
- Updated
- 2021/12/16
- Product number
- CS-W006219
- Product name
- Methyl3-amino-1H-pyrazole-5-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI) Chemical Properties,Usage,Production
Uses
5-Amino-1H-pyrazole-3-carboxylic acid methyl ester is a carboxylic acid ester derivative and an intermediate in the synthesis of a drug for treating cardiovascular diseases.
Synthesis
181585-93-3
632365-54-9
The general procedure for the synthesis of methyl 5-amino-1H-pyrazole-3-carboxylate from methyl 5-nitro-1H-pyrazole-3-carboxylate was as follows: methyl 5-nitro-1H-pyrazole-3-carboxylate (22.35 g, 130.61 mmol) was dissolved in a solvent mixture of 160 mL tetrahydrofuran (THF) and 160 mL glacial acetic acid. Subsequently, 10% palladium-carbon catalyst (Pd-C, 4.36 g) was added and the reaction was stirred at room temperature in a hydrogen atmosphere for 6 days. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the solvent was evaporated under reduced pressure. The crude product was dissolved in 800 mL of dichloromethane, 200 g of sodium bicarbonate was added, filtered and the solvent was again evaporated under reduced pressure. This operation was repeated until there was no acetic acid odor. Methyl 5-amino-1H-pyrazole-3-carboxylate was finally obtained in high yield (16.91 g, 91.7% yield).
References
[1] Patent: US2008/32998, 2008, A1. Location in patent: Page/Page column 20
[2] Patent: WO2011/15343, 2011, A1. Location in patent: Page/Page column 41
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 165
[4] Patent: WO2003/101993, 2003, A1. Location in patent: Page 34-35
[5] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 305
1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI) manufacturers
- Product
- 1H-Pyrazole-3-carboxylicacid,5-amino-,methylester(9CI) 632365-54-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07