2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 4815-36-5
- Chemical Name
- 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- AURORA 20210;AKOS B000514;AKOS MSC-0434;BUTTPARK 30\06-09;AKOS BBS-00002683;ART-CHEM-BB B000514;IFLAB-BB F1018-1557;CHEMBRDG-BB 3000514;TIMTEC-BB SBB006987;2-AMino-4-phenylthiophene-3-carboxylate
- CBNumber
- CB1129601
- Molecular Formula
- C13H13NO2S
- Formula Weight
- 247.31
- MOL File
- 4815-36-5.mol
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 92-97 °C
- Boiling point:
- 391.0±42.0 °C(Predicted)
- Density
- 1.231
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 20 mg/ml
- form
- A crystalline solid
- pka
- -0.14±0.10(Predicted)
- InChI
- 1S/C13H13NO2S/c1-2-16-13(15)11-10(8-17-12(11)14)9-6-4-3-5-7-9/h3-8H,2,14H2,1H3
- InChIKey
- WYTHTMKMOSPACP-UHFFFAOYSA-N
- SMILES
- CCOC(=O)c1c(N)scc1-c2ccccc2
- CAS DataBase Reference
- 4815-36-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 717401
- Product name
- Ethyl 2-amino-4-phenylthiophene-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $61.8
- Updated
- 2023/01/07
- Product number
- 13387
- Product name
- ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $16
- Updated
- 2024/03/01
- Product number
- 13387
- Product name
- ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 13387
- Product name
- ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 13387
- Product name
- ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $56
- Updated
- 2024/03/01
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Uses
Ethyl 2-Amino-4-phenylthiophene-3-carboxylate is used in the design and synthesis of thieno[2,3-d]pyrimidine analogs which exhibits antiproliferative activity against human cancer cells such as liver, pancreatic and colorectal cancer.
Uses
2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester is a synthetic intermediate useful for pharmaceutical synthesis.
Synthesis
17277-47-3
4815-36-5
Ethyl 2-cyano-3-phenylbut-2-enoate (513.25 g, 2.3 mol) was slowly added to a vigorously stirred ethanol (500 mL) suspension of sulfur powder (76 g, 2.3 mol) at room temperature. Subsequently, diethylamine (200 mL) was added in batches over a period of 20 min, and the temperature was raised to 62 °C during the reaction. Upon completion of the reaction, the mixture was cooled to 36 °C, then heated to 50 °C and stirred continuously for 1 h at this temperature. After stopping stirring, unreacted sulfur was removed by decantation and the hot solution was cooled to room temperature. The resulting orange solid product, ethyl 2-amino-4-phenylthiophene-3-carboxylate (195 g) was collected by filtration and washed with a small amount of cold ethanol and finally dried under vacuum. The resulting product was used for subsequent experiments without further purification.
References
[1] Synthetic Communications, 2007, vol. 37, # 23, p. 4273 - 4279
[2] Patent: WO2012/131379, 2012, A1. Location in patent: Page/Page column 19
[3] Patent: US2014/206703, 2014, A1. Location in patent: Paragraph 0033; 0084; 0085
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 4815-36-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11