2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
- Product Name
- 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
- CAS No.
- 233276-38-5
- Chemical Name
- 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
- Synonyms
- 4-Methyltetrahydro-2H-pyran-4-carboxylic acid;4-Methyltetrahydro-2H-pyr...;4-Methyloxane-4-carboxylic acid;4-Methyltetrahydropyran-4-carboxylic Acid;Tetrahydro-4-methyl-2H-pyran-4-carboxylic acid;2H-Pyran-4-carboxylicacid,tetrahydro-4-Methyl-;2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI)
- CBNumber
- CB11298164
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 233276-38-5.mol
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Property
- Boiling point:
- 257℃
- Density
- 1.124
- Flash point:
- 105℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.56±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M219325
- Product name
- 4-Methyltetrahydro-2H-pyran-4-carboxylicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M219325
- Product name
- 4-Methyltetrahydro-2H-pyran-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P000391599
- Product name
- 4-Methyltetrahydro-2H-pyran-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- P000391599
- Product name
- 4-Methyltetrahydro-2H-pyran-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- P000391599
- Product name
- 4-Methyltetrahydro-2H-pyran-4-carboxylic acid
- Purity
- 96+%
- Packaging
- 1g
- Price
- $94
- Updated
- 2021/12/16
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Chemical Properties,Usage,Production
Synthesis
443912-70-7
233276-38-5
The general procedure for the synthesis of 4-methyltetrahydropyran-4-carboxylic acid from methyl 4-methyl-tetrahydro-2H-pyran-4-carboxylate was as follows: to a solution of methyl 4-methyltetrahydro-2H-pyran-4-carboxylate (5.00 g, 31.6 mmol) in a 1:1:1 mixed solvent of dioxane/water/methanol (60 mL), lithium hydroxide hydrate (5.31 g, 126 mmol) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was partially concentrated and subsequently diluted with water and ethyl acetate (EtOAc) and acidified with 6 M hydrochloric acid to pH=1. The organic and aqueous layers were separated and the aqueous layer was extracted with additional ethyl acetate (50 mL). All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness to afford 4-methyltetrahydro-2H-pyran-4-carboxylic acid (4.61 g, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 12.29 (s, 1H), 3.65 (dt, J=11.8,4.3 Hz, 2H), 3.33-3.32 (m, 2H), 1.87-1.86 (m, 2H), 1.35 (ddd, J=13.5,9.9,4.1 Hz, 2H). 1.13 (s, 3H).
References
[1] Patent: US2014/275016, 2014, A1. Location in patent: Paragraph 0266
[2] Patent: US2014/275080, 2014, A1. Location in patent: Paragraph 0400
[3] ChemMedChem, 2010, vol. 5, # 1, p. 65 - 78
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 15921303235
- Fax
- QQ489466966
- sales@synthfine.com
- Country
- China
- ProdList
- 1042
- Advantage
- 58
- Tel
- 028-85114309 18982182443
- yangli@happysyn.com
- Country
- China
- ProdList
- 2151
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4108
- Advantage
- 58
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
View Lastest Price from 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) manufacturers
- Product
- 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-(9CI) 233276-38-5
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23