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5,7-dihydroxychromone

Product Name
5,7-dihydroxychromone
CAS No.
31721-94-5
Chemical Name
5,7-dihydroxychromone
Synonyms
Dihydroxychromone;7-Dihydroxychromone;5,7-Dihydroxy-4-chromone;5,7-Dihydroxychromone-RM;5,7-Dihydroxychromen-4-one;5,7-Dihydroxy-4H-chroMen-4-one;5,7-Dihydroxy-γ-chromene-4-one;5,7-Dihydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-;Arenavirus,5,7 Dihydroxychromone,inhibit,Inhibitor,PARP,Caspase,Keap1-Nrf2,5,7-Dihydroxychromone,5,7Dihydroxychromone,poly ADP ribose polymerase
CBNumber
CB11304153
Molecular Formula
C9H6O4
Formula Weight
178.14
MOL File
31721-94-5.mol
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5,7-dihydroxychromone Property

Melting point:
232-273℃
Boiling point:
399℃
Density 
1.563
Flash point:
171℃
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥5.41 mg/mL in EtOH with gentle warming; ≥7.05 mg/mL in DMSO
form 
solid
pka
6.57±0.20(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL83494
Product name
5,7-Dihydroxychromone
Purity
phyproof? Reference Substance
Packaging
20mg
Price
$344
Updated
2024/03/01
Cayman Chemical
Product number
29006
Product name
5,7-Dihydroxychromone
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
29006
Product name
5,7-Dihydroxychromone
Packaging
5mg
Price
$160
Updated
2024/03/01
Cayman Chemical
Product number
29006
Product name
5,7-Dihydroxychromone
Packaging
10mg
Price
$239
Updated
2024/03/01
ApexBio Technology
Product number
N2172
Product name
5,7-dihydroxychromone
Packaging
10mM(in 1mL DMSO)
Price
$50
Updated
2021/12/16
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5,7-dihydroxychromone Chemical Properties,Usage,Production

Description

5,7-Dihydroxychromone is a flavone decomposition product that has been found in A. hypogaea and has diverse biological activities, including antimicrobial, antioxidant, and neuroprotective properties. It reduces radial growth of the soil pathogenic fungi R. solani and S. rolfsii (IC50s = 18 and 26 μM, respectively) but has no effect on soil pathogenic bacteria of the genus Bradyrhizobium. 5,7-Dihydroxychromone (0.4, 2, and 10 μM) reduces increases in apoptosis and the levels of reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y neuroblastoma cells. It also increases the levels of HO-1, NQO1, and GCLc in SH-SY5Y cells when used at concentrations ranging from 0.08 to 10 μM.

Definition

ChEBI: 5,7-Dihydroxychromone is a member of chromones.

in vitro

5,7-dihydroxychromone (dhc) (0.4–10 μm) was found to protect against neuronal cell death and the ros generation in a dose-dependent manner in 6-ohda-induced sh-sy5y cells. dhc (0.08–10 μm) also dose-dependently increased the induction of nuclear nrf2, which has a binding affinity to are and activates are-driven phase ii antioxidant enzymes; nqo1, ho-1, and gclc[1]. daphniphyllum macropodum fruit extract (dme) administration in vivo and its major component 5,7-dihydroxychromone (1, 5, and 10 μg/ml) treatment in vitro dose dependently increased the mrna expressions of pparγ and lxrα in 3t3-l1 cells, 5,7-dihydroxychromone (1 μg/ml ) also potently increased adipocyte differentiation, suggesting that it functions as a pparγ agonist and has anti-diabetic properties[2]. 5,7-dihydroxychromone also demonstrated significant activity against hiv replication in h9 lymphocyte cells[3].

References

[1]. kim d w, lee k, kwon j, et al. neuroprotection against 6-ohda-induced oxidative stress and apoptosis in sh-sy5y cells by 5, 7-dihydroxychromone: activation of the nrf2/are pathway[j]. life sciences, 2015, 130: 25-30.
[2]. koo h j, kwak j h, kang s c. anti-diabetic properties of daphniphyllum macropodum fruit and its active compound[j]. bioscience, biotechnology, and biochemistry, 2014, 78(8): 1392-1401.
[3]. wu p l, lin f w, wu t s, et al. cytotoxic and anti-hiv principles from the rhizomes of begonia nantoensis[j]. chemical and pharmaceutical bulletin, 2004, 52(3): 345-349.

5,7-dihydroxychromone Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-dihydroxychromone Suppliers

China 121 India 1 United Kingdom 1 United States 11 USA 1 Global 135
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
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China
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6005
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61
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
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China
ProdList
5653
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
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China
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2376
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Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
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China
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925
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58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
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66
Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
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Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
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50
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
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Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
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View Lastest Price from 5,7-dihydroxychromone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5,7-dihydroxychromone 31721-94-5
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-21
Shanghai Standard Technology Co., Ltd.
Product
5,7-dihydroxychromone 31721-94-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-16
Career Henan Chemical Co
Product
5,7-dihydroxychromone 31721-94-5
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

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