Mangostin
- Product Name
- Mangostin
- CAS No.
- 6147-11-1
- Chemical Name
- Mangostin
- Synonyms
- mangostin;NSC 27593;NSC 30552;NSC 139154;MANGOSTINE;Mangosteen;α-Mangosten;a-Mangosten;a-Mangostin;α-mangostin
- CBNumber
- CB0739500
- Molecular Formula
- C24H26O6
- Formula Weight
- 410.46
- MOL File
- 6147-11-1.mol
Mangostin Property
- Melting point:
- 180-182°C
- Boiling point:
- 640.1±55.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- methanol: soluble1mg/mL, clear, very light yellow
- pka
- 7.22±0.20(Predicted)
- form
- powder
- color
- faint yellow to yellow
- λmax
- 346nm(MeOH)(lit.)
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
- InChIKey
- GNRIZKKCNOBBMO-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
- CAS DataBase Reference
- 6147-11-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 1
- RTECS
- ZD6122420
- HS Code
- 29329990
- Hazardous Substances Data
- 6147-11-1(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- M3824
- Product name
- α-Mangostin
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $248
- Updated
- 2024/03/01
- Product number
- M3824
- Product name
- α-Mangostin
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $785
- Updated
- 2024/03/01
- Product number
- PHL89247
- Product name
- Mangostin
- Purity
- phyproof? Reference Substance
- Packaging
- 25MG
- Price
- $317
- Updated
- 2023/01/07
- Product number
- 07589
- Product name
- α-Mangostin
- Purity
- analytical standard
- Packaging
- 25MG
- Price
- $696
- Updated
- 2022/05/15
- Product number
- M2793
- Product name
- α-Mangostin
- Purity
- >97.0%(HPLC)
- Packaging
- 10mg
- Price
- $86
- Updated
- 2024/03/01
Mangostin Chemical Properties,Usage,Production
Description
α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5
Chemical Properties
Yellow Crystalline Solid
Uses
It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent
Uses
antifungal, antilarval
Uses
α-Mangostin has been used:
- to study its protective effect against oxidative stress mediated-retinal cell death
- to study its role as an antigenotoxic agent in DNA protection against oxidative damage
- to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A
Definition
ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.
storage
Store at -20°C
References
1) Mohan et al. (2018), An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach; Food Funct., 9 3860 2) Zhang et al. (2018), Identification of α-Mangostin as an Agonist of Human STING; Chem. Med. Chem.,?13 2057 3) Lee et al. (2018), Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-induced Damage; J. Mol. Sci., 19 E1484 4) Chen et al. (2017), Alpha-Mangostin Suppresses the Metastasis of Human renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity; Cell Physiol. Biochem., 44 1460 5) Xia and Sun (2018), Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment; Clin. Exp. Dermatol., 43 149
Mangostin Preparation Products And Raw materials
Raw materials
Preparation Products
Mangostin Suppliers
- Tel
- 18122150900
- Fax
- QQ:2869377561
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- China
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- 0731-84213302 18374838656
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- China
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- 025-83697070
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- +86-25-83453306
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- 021-50135380
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- 021-55068248
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View Lastest Price from Mangostin manufacturers
- Product
- Mangosteen Peel Extract / Alpha Mangostin 6147-11-1
- Price
- US $180.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-23
- Product
- Fructus monordicae extract
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 10%-50% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-10-08
- Product
- Mangostin; α-Mangostin 6147-11-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 1%-98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-12-08