Mangostin
- Product Name
- Mangostin
- CAS No.
- 6147-11-1
- Chemical Name
- Mangostin
- Synonyms
- mangostin;NSC 27593;NSC 30552;NSC 139154;MANGOSTINE;Mangosteen;α-Mangosten;a-Mangosten;a-Mangostin;α-mangostin
- CBNumber
- CB0739500
- Molecular Formula
- C24H26O6
- Formula Weight
- 410.46
- MOL File
- 6147-11-1.mol
Mangostin Property
- Melting point:
- 180-182°C
- Boiling point:
- 640.1±55.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- methanol: soluble1mg/mL, clear, very light yellow
- pka
- 7.22±0.20(Predicted)
- form
- powder
- color
- faint yellow to yellow
- λmax
- 346nm(MeOH)(lit.)
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
- InChIKey
- GNRIZKKCNOBBMO-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
- CAS DataBase Reference
- 6147-11-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 1
- RTECS
- ZD6122420
- HS Code
- 29329990
- Hazardous Substances Data
- 6147-11-1(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- M3824
- Product name
- α-Mangostin
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $255
- Updated
- 2025/07/31
- Product number
- PHL89247
- Product name
- Mangostin
- Purity
- phyproof? Reference Substance
- Packaging
- 25MG
- Price
- $340
- Updated
- 2025/07/31
- Product number
- M3824
- Product name
- α-Mangostin
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $807
- Updated
- 2025/07/31
- Product number
- 07589
- Product name
- α-Mangostin
- Purity
- analytical standard
- Packaging
- 25MG
- Price
- $696
- Updated
- 2022/05/15
- Product number
- M2793
- Product name
- α-Mangostin
- Purity
- >97.0%(HPLC)
- Packaging
- 10mg
- Price
- $86
- Updated
- 2025/07/31
Mangostin Chemical Properties,Usage,Production
Description
α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5
Chemical Properties
Yellow Crystalline Solid
Uses
It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent
Uses
antifungal, antilarval
Uses
α-Mangostin has been used:
- to study its protective effect against oxidative stress mediated-retinal cell death
- to study its role as an antigenotoxic agent in DNA protection against oxidative damage
- to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A
Definition
ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.
storage
Store at -20°C
References
[1] MOHAN S, SYAM S, ABDELWAHAB S I, et al. An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach[J]. Food & Function, 2018, 7: 3860-3871. DOI:10.1039/c8fo00439k
[2] DR. YIBO ZHANG. Identification of α-Mangostin as an Agonist of Human STING[J]. ChemMedChem, 2018, 13 19: 2057-2064. DOI:10.1002/cmdc.201800481
[3] DAHAE LEE. Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage.[J]. International Journal of Molecular Sciences, 2018, 19 5. DOI:10.3390/ijms19051484
[4] CHIEN-MIN CHEN. Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity.[J]. Cellular Physiology and Biochemistry, 2017: 1460-1470. DOI:10.1159/000485582
[5] Y. XIA J. S. Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment[J]. Clinical and Experimental Dermatology, 2017, 43 2: 149-157. DOI:10.1111/ced.13283
Mangostin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mangostin manufacturers
- Product
- mangostin 6147-11-1
- Price
- US $1200.00-1100.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 27
- Release date
- 2025-11-06
- Product
- Mangostin 6147-11-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- Mangostin; α-Mangostin 6147-11-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 1%-98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-12-08