ChemicalBook > CAS DataBase List > Mangostin

Mangostin

Product Name
Mangostin
CAS No.
6147-11-1
Chemical Name
Mangostin
Synonyms
mangostin;NSC 27593;NSC 30552;NSC 139154;MANGOSTINE;Mangosteen;α-Mangosten;a-Mangosten;a-Mangostin;α-mangostin
CBNumber
CB0739500
Molecular Formula
C24H26O6
Formula Weight
410.46
MOL File
6147-11-1.mol
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Mangostin Property

Melting point:
180-182°C
Boiling point:
640.1±55.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, very light yellow
pka
7.22±0.20(Predicted)
form 
powder
color 
faint yellow to yellow
λmax
346nm(MeOH)(lit.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI
InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey
GNRIZKKCNOBBMO-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
CAS DataBase Reference
6147-11-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
1
RTECS 
ZD6122420
HS Code 
29329990
Hazardous Substances Data
6147-11-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3824
Product name
α-Mangostin
Purity
≥98% (HPLC)
Packaging
10mg
Price
$248
Updated
2024/03/01
Sigma-Aldrich
Product number
M3824
Product name
α-Mangostin
Purity
≥98% (HPLC)
Packaging
50mg
Price
$785
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89247
Product name
Mangostin
Purity
phyproof? Reference Substance
Packaging
25MG
Price
$317
Updated
2023/01/07
Sigma-Aldrich
Product number
07589
Product name
α-Mangostin
Purity
analytical standard
Packaging
25MG
Price
$696
Updated
2022/05/15
TCI Chemical
Product number
M2793
Product name
α-Mangostin
Purity
>97.0%(HPLC)
Packaging
10mg
Price
$86
Updated
2024/03/01
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Mangostin Chemical Properties,Usage,Production

Description

α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5

Chemical Properties

Yellow Crystalline Solid

Uses

It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent

Uses

antifungal, antilarval

Uses

α-Mangostin has been used:

  • to study its protective effect against oxidative stress mediated-retinal cell death
  • to study its role as an antigenotoxic agent in DNA protection against oxidative damage
  • to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A

Definition

ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.

storage

Store at -20°C

References

1) Mohan et al. (2018), An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach; Food Funct., 9 3860 2) Zhang et al. (2018), Identification of α-Mangostin as an Agonist of Human STING; Chem. Med. Chem.,?13 2057 3) Lee et al. (2018), Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-induced Damage; J. Mol. Sci., 19 E1484 4) Chen et al. (2017), Alpha-Mangostin Suppresses the Metastasis of Human renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity; Cell Physiol. Biochem., 44 1460 5) Xia and Sun (2018), Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment; Clin. Exp. Dermatol., 43 149

Mangostin Preparation Products And Raw materials

Raw materials

Preparation Products

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Mangostin Suppliers

Americas 1 Canada 1 CHINA 244 Europe 1 Germany 2 India 6 Japan 1 United Kingdom 5 United States 23 Global 284
Guangzhou Zhiya Chemdrugs Co.,Ltd
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View Lastest Price from Mangostin manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Fructus monordicae extract
Price
US $0.00/KG
Min. Order
1KG
Purity
10%-50% HPLC
Supply Ability
1000KG
Release date
2022-10-08
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Mangostin; α-Mangostin 6147-11-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
1%-98% HPLC
Supply Ability
1000KG
Release date
2022-12-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Mangosteen Peel Extract / Alpha Mangostin 6147-11-1
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-23

6147-11-1, MangostinRelated Search:

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  • α-Mangostin, 98%, from Garcinia mangostana
  • α-Mangostin (a-Mangostin、ALPHA-Mangostin)
  • α-Mangostin, froM Garcinia Mangostana
  • 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on
  • Alpha-Mangostin α-Mangostin
  • 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
  • 1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE
  • Mangosteen
  • mangostin
  • MANGOSTINE
  • NSC 139154
  • NSC 27593
  • NSC 30552
  • α-Mangosten
  • a-Mangosten
  • a-Mangostin
  • Momordica Fruit P.E.
  • Fructus Monordicae extract
  • 1,3,6-Trihydroxy-2,8-diprenyl-7-methoxy-9H-xanthene-9-one
  • 7-Methoxy-1,3,6-trihydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthene-9-one
  • Xango, Mangostan, Queen of fruits
  • 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone
  • 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
  • 1,3,6-Trihydroxy-7-Methoxy-2,8-bis(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one
  • 1,3,6-Trihydroxy-7-Methoxy-2,8-bis(3-Methyl-2-butenyl)-9H-xanten-9-one
  • 9H-Xanthen-9-one, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-
  • 9H-Xanthen-9-one,1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-
  • α-mangostin
  • Low poly fructose
  • Shanzhu fruit powder
  • GARCININA MANGOSTEEN POWDER
  • Mangostin USP/EP/BP
  • 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
  • TIANFU-CHEM Mangostin
  • α- Reverse twister
  • α- Inverted twister element
  • Mangostin Α, Β, Γ
  • Alpha-Mangostin α-Mangostin
  • α-Mangostin (a-Mangostin、ALPHA-Mangostin)
  • Mangosteen Peel Extract / Alpha Mangostin
  • 6147-11-1
  • 931-37-7
  • 11/1/6147
  • reagent
  • standard substance
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Xanthones
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical