ChemicalBook > CAS DataBase List > Survodutide

Survodutide

Product Name: Survodutide
CAS No.: 2805997-46-8
Chemical Name: Survodutide
Synonyms: Suvorouti;BI 456906;Suvodutide;Survodutide;Swertide peptide;Survodutide 10mg;Survodutide Peptide;Survodutide acetate;Survodutide(BI 456906) 10MG
CBNumber: CB113380978
Formula Weight: 0
MOL File: Mol file

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Survodutide Property

solubility: PBS (pH 7.2): Soluble: =10 mg/ml
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Survodutide Chemical Properties,Usage,Production

Uses

Survodutide is a dual glucagon/glucagon-like peptide 1 (GLP1) receptor agonist. Survodutide has demonstrated blood sugar lowering efficacy in a Phase II trial for the treatment of patients with type 2 diabetes and obesity and was associated with clinically meaningful weight loss^[1]. Survodutide is also being studied for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)^[2].

in vivo

Survodutide (BI 456906; 3, 10, 20, 30 nmol/kg; SC; daily; 30 days) achieves a greater bodyweight-lowering efficacy in diet-induced obese mice compared with maximally effective doses of Semaglutide (HY-114118; 20, 100 nmol/kg). Survodutide dose-dependently reduces plasma glucagon^[1].
Survodutide (1, 3, 10, 30, 100 nmol/kg; SC; single dose) dose-dependently reducesacute food intake in WT but not in GLP-1R KO mice (Three-week-old, male, lean NMRI outbred mice)^[1].
Survodutide (1, 3, 10, 30, 100 nmol/kg; SC; single dose) engages the glucagon receptor in vivo upon single dosing, increases liver nicotinamide N-methyltransferase mRNA, and reduces plasma serine and glutamine^[1].
Survodutide (SC injection) causes mean residence times of 44 and 140 h and T_max values of 7 and 51 h obtained in mice and dogs, respectively^[1].
Pharmacokinetic Parameters of Survodutide (BI 456906) in mice and dogs^[1].

	Mice (20 nmol/kg; SC)	Dogs (10 nmol/kg; SC)
T_max (h)	7	50.7
C_max (nM)	84.9	62.0
AUC_0-∞ (nM?h)	4640	9540

Animal Model:	Male C57BL6/J mice pre-fed with a 60% HFD (22 weeks)^[1]
Dosage:	3, 10, 20, 30 nmol/kg
Administration:	SC; daily; 30 days
Result:	Dose-dependently reduced bodyweight from baseline by up to 32% at Day 28 at a dose of 30 nmol/kg.

References

[1] BRIAND F, AUGUSTIN R, WESCHE F, et al. 1635-P: Survodutide Weight Loss Is Associated with Changes in Food Preference and Improvement of Dyslipidemia in the Free Choice Diet–Induced Obese Hamster Model[J]. Diabetes, 2024, 33 2. DOI:10.2337/db24-1635-p.
[2] Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis[J]. Journal of Hepatology, 2024, 81 5: Pages 837-846. DOI:10.1016/j.jhep.2024.06.003.
[3] TINA ZIMMERMANN . BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy[J]. Molecular Metabolism, 2022, 66: Article 101633. DOI: 10.1016/j.molmet.2022.101633

Survodutide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Survodutide manufacturers

Hainan Fubai Trading Co., LTD

Product: Survodutide 2805997-46-8
Price: US $70.00/box
Min. Order: 1box
Purity: 99
Supply Ability: 999
Release date: 2025-11-07

Hebei Dangtong Import and export Co LTD

Product: Survodutide 2805997-46-8
Price: US $620.00-56500.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1000g
Release date: 2025-10-31

Shanghai Yimeixin Technology Co., LTD

Product: Survodutide 2805997-46-8
Price: US $0.00/box
Min. Order: 1box
Purity: 0.99
Supply Ability: 10tons
Release date: 2025-09-26

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2805997-46-8