ChemicalBook > CAS DataBase List > macbecin I
macbecin I
- Product Name
- macbecin I
- CAS No.
- 73341-72-7
- Chemical Name
- macbecin I
- Synonyms
- Macbecin;macbecin I;(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin;(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin;Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
- CBNumber
- CB11346962
- Molecular Formula
- C30H42N2O8
- Formula Weight
- 558.67
- MOL File
- 73341-72-7.mol
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macbecin I Property
- Melting point:
- 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 736.2±60.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 8.62±0.70(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22225
- Product name
- Macbecin I
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $291
- Updated
- 2024/03/01
Tocris
- Product number
- 3061
- Product name
- MacbecinI
- Packaging
- 1
- Price
- $311
- Updated
- 2021/12/16
Usbiological
- Product number
- 255749
- Product name
- Macbecin I
- Packaging
- 1mg
- Price
- $573
- Updated
- 2021/12/16
TRC
- Product number
- M107525
- Product name
- MacbecinI
- Packaging
- 0.5mg
- Price
- $1200
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B7259
- Product name
- MacbecinI
- Packaging
- 1mg
- Price
- $465
- Updated
- 2021/12/16
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macbecin I Chemical Properties,Usage,Production
Uses
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.
Biological Activity
Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
macbecin I Preparation Products And Raw materials
Raw materials
Preparation Products
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