DIETHYL (N-METHOXY-N-METHYLCARBAMOYLMETHYL)PHOSPHONATE Property

Boiling point:

90 °C17 mm Hg(lit.)

Density 

1.163 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.455(lit.)

Flash point:

>230 °F

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

1875865

CAS DataBase Reference

124931-12-0

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29319000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DIETHYL (N-METHOXY-N-METHYLCARBAMOYLMETHYL)PHOSPHONATE Chemical Properties,Usage,Production

Uses

Reactant for:

• Preparation of ring-expanded bryostatin analogs as antitumor agents
• Asymmertic synthesis of pinnatoxins A and G via diastereoselective Ireland-Claisen rearrangement, ring closing metathesis, and cyclization
• Rh2(II)-catalyzed nitro-group migration reactions
• Stereoselective synthesis of cyclohexanones via phase transfer catalyzed double addition reactions
• Stereoselective synthesis of (+)-polyrhacitide A via aldol reaction, Horner-Wardsworth-Emmons reaction, Evans acetal intramolecular oxa-Michael reaction and diastereoselective syn reduction reaction as the key steps
• Preparation of substituted furans via olefin cross-metathesis