spinorphin

ChemicalBook > CAS DataBase List > spinorphin

Product Name: spinorphin
CAS No.: 137201-62-8
Chemical Name: spinorphin
Synonyms: LVVYPWT;spinorphin;Spinorphin 137201-62-8;inhibit,Inhibitor,Spinorphin;L-Threonine, L-leucyl-L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-
CBNumber: CB11350574
Molecular Formula: C45H64N8O10
Formula Weight: 877.04
MOL File: 137201-62-8.mol

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spinorphin Property

storage temp.: Desiccate at -20°C
solubility: Soluble to 1 mg/ml in H2O
form: solid
color: White
Water Solubility: Soluble to 1 mg/ml in water
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29914
Product name: Spinorphin
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 29914
Product name: Spinorphin
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 29914
Product name: Spinorphin
Packaging: 5mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 29914
Product name: Spinorphin
Packaging: 10mg
Price: $535
Updated: 2024/03/01

Tocris

Product number: 2931
Product name: Spinorphin
Packaging: 1
Price: $115
Updated: 2021/12/16

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spinorphin Chemical Properties,Usage,Production

Uses

Spinorphin is a novel neuropeptide, which exhibits complete inhibition of agonist-induced nociception.It is peptide analogs with branched amino acid probes and their therapeutic use.

Definition

ChEBI: Spinorphin is an oligopeptide.

Biological Activity

spinorphin is an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase iii, angiotensin-converting enzyme and enkephalinase) [1]. also, it is a potent antagonist of human p2x3 receptor and the n-formylpeptide receptor subtype fpr with ic50 value of 8.3 pm for p2x3 receptor[2][3].enkephalin degrading enzymes are a series of enzymes that hydrolyze enkephalins, which play an important role in management of blood pressure, pain, hypertension and cardiovascular diseases.in human embryonic kidney (hek) 293 cells transfected with mouse fpr, spinorphin induced a typical rise in the intracellular ca2+ concentration with ec50 of 128 μm. also, in normal mouse neutrophils, spinorphin induced calcium flux in a dose-dependent way. while the neutrophils from mice deficient in the fmlf receptor subtype fpr didn’t response [3].in mice, intrathecal administration of spinorphin inhibited the allodynia induced by intrathecal nociceptin in a dose-dependent way. furthermore, spinorphin enhanced the inhibitory effect of enkephalin on allodynia induced by nociceptin [4].

References

[1]. nishimura k, hazato t. isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord. biochem biophys res commun, 1993, 194(2): 713-719.
[2]. jung ky, moon hd, lee ge, et al. structure-activity relationship studies of spinorphin as a potent and selective human p2x(3) receptor antagonist. j med chem, 2007, 50(18): 4543-4547.
[3]. liang ts, gao jl, fatemi o, et al. the endogenous opioid spinorphin blocks fmet-leu-phe-induced neutrophil chemotaxis by acting as a specific antagonist at the n-formylpeptide receptor subtype fpr. j immunol, 2001, 167(11): 6609-6614.
[4]. honda m, okutsu h, matsuura t, et al. spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. jpn j pharmacol, 2001, 87(4): 261-267.

spinorphin Preparation Products And Raw materials

Raw materials

Preparation Products

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137201-62-8, spinorphinRelated Search:

hIRBP651-670 Orexin B, human TFA GALANIN, HUMAN APELIN-36 (HUMAN) H-TRP-SER-OH spinorphin

spinorphin

Spinorphin 137201-62-8

L-Threonine, L-leucyl-L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-

LVVYPWT

inhibit,Inhibitor,Spinorphin

137201-62-8

Purinergics P2 receptor